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Background <p>Despite decades of research, the underlying mechanism of auditory verbal hallucinations (AVH), a core symptom of schizophrenia, remain unclear. Previous studies have tried to capture the neural activity during AVH episodes, whereas trait features of AVH have been less investigated. To address this gap, we employed functional Near-Infrared Spectroscopy (fNIRS) to investigate the neuroimaging patterns in healthy controls (HCs), patients with schizophrenia with a history of AVH (AVHh+) and those without a history of AVH history (AVHh-). We hypothesized that significant differences of functional connectivity (FC) changes would be observed in AVHh+.</p> Method <p>We recruited 23 AVHh+, 16 AVHh-, and 17 matched HCs. Participants underwent an 8-minute resting-state fNIRS scanning. Data processing and analysis were conducted by the NirSpark software (HuiChuang, China) package and R Studio.</p> Result <p>Compared to the AVHh-, the AVHh+ showed significantly lower FC between the Broca's area and the left supplementary motor area (SMA).</p> Conclusion <p>The hypoconnectivity of Broca-left SMA circuit might serve as a trait-like marker of vulnerability to AVH.</p>

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Decreased Broca-left supplementary motor area connectivity underlying auditory verbal hallucination: A resting-state NIRS study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月2日

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  • Zetao Huang,
  • Yingding Ma,
  • Jiuju Wang,
  • Yanping Song,
  • Jiaxin Zhang,
  • Ziyu Ye,
  • Dafang Ouyang,
  • Daijun Ke,
  • De Cao,
  • Wentian Dong

摘要

Background

Despite decades of research, the underlying mechanism of auditory verbal hallucinations (AVH), a core symptom of schizophrenia, remain unclear. Previous studies have tried to capture the neural activity during AVH episodes, whereas trait features of AVH have been less investigated. To address this gap, we employed functional Near-Infrared Spectroscopy (fNIRS) to investigate the neuroimaging patterns in healthy controls (HCs), patients with schizophrenia with a history of AVH (AVHh+) and those without a history of AVH history (AVHh-). We hypothesized that significant differences of functional connectivity (FC) changes would be observed in AVHh+.

Method

We recruited 23 AVHh+, 16 AVHh-, and 17 matched HCs. Participants underwent an 8-minute resting-state fNIRS scanning. Data processing and analysis were conducted by the NirSpark software (HuiChuang, China) package and R Studio.

Result

Compared to the AVHh-, the AVHh+ showed significantly lower FC between the Broca's area and the left supplementary motor area (SMA).

Conclusion

The hypoconnectivity of Broca-left SMA circuit might serve as a trait-like marker of vulnerability to AVH.