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<p>Advances in genotyping and DNA sequencing have led to the discovery of many schizophrenia-associated loci and new and unexpected pathophysiological mechanisms. Despite this tremendous progress, only a small proportion of the Schizophrenia risk can be linked to the biological or physiological mechanisms. This has led to the development of many post-GWAS methods to further explore the mechanisms behind phenotypes and diseases. In this review we will give an overview of the current computational and experimental approaches that can convert the GWAS results into insights into the underlying causal architecture of Schizophrenia.</p>

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A review of post-GWAS studies in schizophrenia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月31日

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  • Shahin Maserrat,
  • Murray J. Cairns

摘要

Advances in genotyping and DNA sequencing have led to the discovery of many schizophrenia-associated loci and new and unexpected pathophysiological mechanisms. Despite this tremendous progress, only a small proportion of the Schizophrenia risk can be linked to the biological or physiological mechanisms. This has led to the development of many post-GWAS methods to further explore the mechanisms behind phenotypes and diseases. In this review we will give an overview of the current computational and experimental approaches that can convert the GWAS results into insights into the underlying causal architecture of Schizophrenia.