Scholarlink

<p>Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, <i>p</i><sub><i>FDR</i></sub> = 0.04) and fronto-temporal (β = 0.024, <i>p</i><sub><i>FDR</i></sub> = 0.01) volumes, but negatively with parietal (β = −0.037, <i>p</i><sub><i>FDR</i></sub> = 0.04) and parieto-occipital (β = −0.033, <i>p</i><sub><i>FDR</i></sub> = 0.01) volumes. This preliminary result suggests the potential involvement of ASD common genetic variants in early structural variations linked to ASD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月5日

查看全文
  • Hai Le,
  • Daphna Fenchel,
  • Konstantina Dimitrakopoulou,
  • Hamel Patel,
  • Charles Curtis,
  • Lucilio Cordero-Grande,
  • A. David Edwards,
  • Joseph Hajnal,
  • Jacques-Donald Tournier,
  • Maria Deprez,
  • Harriet Cullen

摘要

Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, pFDR = 0.04) and fronto-temporal (β = 0.024, pFDR = 0.01) volumes, but negatively with parietal (β = −0.037, pFDR = 0.04) and parieto-occipital (β = −0.033, pFDR = 0.01) volumes. This preliminary result suggests the potential involvement of ASD common genetic variants in early structural variations linked to ASD.