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Introduction <p>The Mona Lisa 2.0 robotic platform integrates MRI/ultrasound fusion, AI-based prostate segmentation, and automated needle trajectory planning to optimize transperineal targeted biopsy (TB) precision.</p> Case presentation <p>We report the first European experience in 10 consecutive patients undergoing robot-assisted TB, with optional systematic cores. Clinically significant prostate cancer was detected in all rTB procedures. Standard cores added limited diagnostic yield and mainly sampled perilesional “penumbra” areas. Mean biopsy duration was 12.9 min, no peri- or post-procedural complications occurred, and high-quality tissue samples were consistently obtained.</p> Conclusions <p>These preliminary data confirm feasibility, safety, and reproducibility of Mona Lisa 2.0 robotic platform, as a new kid on the block in urologic robotic armamentarium.</p>

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Robot-assisted MRI/US transperineal target prostate biopsy with Biobot Mona Lisa 2.0: first experience in Europe

  • 期刊论文

  • 发表日期：

    2026年2月25日

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  • Enrico Checcucci,
  • Gabriele Bignante,
  • Gabriele Volpi,
  • Saverio Liguori,
  • Paolo Alessio,
  • Michele Sica,
  • Michele Ortenzi,
  • Daniele Amparore,
  • Alessandra Saliva,
  • Alberto Piana,
  • Stefano De Luca,
  • Alessandro Cerutti,
  • Francesco Porpiglia

摘要

Introduction

The Mona Lisa 2.0 robotic platform integrates MRI/ultrasound fusion, AI-based prostate segmentation, and automated needle trajectory planning to optimize transperineal targeted biopsy (TB) precision.

Case presentation

We report the first European experience in 10 consecutive patients undergoing robot-assisted TB, with optional systematic cores. Clinically significant prostate cancer was detected in all rTB procedures. Standard cores added limited diagnostic yield and mainly sampled perilesional “penumbra” areas. Mean biopsy duration was 12.9 min, no peri- or post-procedural complications occurred, and high-quality tissue samples were consistently obtained.

Conclusions

These preliminary data confirm feasibility, safety, and reproducibility of Mona Lisa 2.0 robotic platform, as a new kid on the block in urologic robotic armamentarium.