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Background <p>Preterm birth is associated with increased morbidity and mortality, including risk for ischemic heart disease and heart failure in adulthood. While smaller coronary size has been reported in preterm children, this has not been reported for adults. We hypothesized that coronary artery size would be reduced in adults born preterm.</p> Methods <p>Cardiac MRI was performed at 1.5 T. Cardiac structure and function were determined using short axis balanced steady state free precession (bSSFP) cine. Left main (LM), left anterior descending (LAD), and right coronary artery (RCA) area and diameter measures were acquired with 3-dimensional bSSFP coronary magnetic resonance angiography imaging.</p> Results <p>Young adults born preterm (gestational age: 27.1 ± 2.2 wks) exhibited smaller LM, LAD, and RCA area and diameter, with a clear dose effect of prematurity after adjusting for sex and left ventricular mass. Although females had smaller coronary artery size regardless of birth status, the smaller coronary artery size among preterm-born adults was primarily driven by males with reductions in LM, LAD, and RCA dimensions.</p> Conclusion <p>In conclusion, we have identified young adults born preterm have smaller coronary artery size, and these findings are highly influenced by sex, with substantial decreases in males born preterm.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Young adults born preterm exhibit smaller coronary artery size compared to age-match term-born adults. These reductions in coronary artery dimensions in the preterm adults were most notable in males.</p> </ItemContent> <ItemContent> <p>Smaller coronary artery diameters have been linked as a potential risk factor for atherosclerosis and increased prevalence of coronary artery disease in certain populations.</p> </ItemContent> <ItemContent> <p>These findings could contribute to higher risk for coronary artery disease in adults born preterm, and predict a higher ischemic burden in men born preterm.</p> </ItemContent> </UnorderedList></p>

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Smaller coronary artery size in adults born preterm

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月13日

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  • Gregory P. Barton,
  • Kavita Sharma,
  • Tarique Hussain,
  • Kara N. Goss

摘要

Background

Preterm birth is associated with increased morbidity and mortality, including risk for ischemic heart disease and heart failure in adulthood. While smaller coronary size has been reported in preterm children, this has not been reported for adults. We hypothesized that coronary artery size would be reduced in adults born preterm.

Methods

Cardiac MRI was performed at 1.5 T. Cardiac structure and function were determined using short axis balanced steady state free precession (bSSFP) cine. Left main (LM), left anterior descending (LAD), and right coronary artery (RCA) area and diameter measures were acquired with 3-dimensional bSSFP coronary magnetic resonance angiography imaging.

Results

Young adults born preterm (gestational age: 27.1 ± 2.2 wks) exhibited smaller LM, LAD, and RCA area and diameter, with a clear dose effect of prematurity after adjusting for sex and left ventricular mass. Although females had smaller coronary artery size regardless of birth status, the smaller coronary artery size among preterm-born adults was primarily driven by males with reductions in LM, LAD, and RCA dimensions.

Conclusion

In conclusion, we have identified young adults born preterm have smaller coronary artery size, and these findings are highly influenced by sex, with substantial decreases in males born preterm.

Impact

Young adults born preterm exhibit smaller coronary artery size compared to age-match term-born adults. These reductions in coronary artery dimensions in the preterm adults were most notable in males.

Smaller coronary artery diameters have been linked as a potential risk factor for atherosclerosis and increased prevalence of coronary artery disease in certain populations.

These findings could contribute to higher risk for coronary artery disease in adults born preterm, and predict a higher ischemic burden in men born preterm.