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Abstract <p>Congenital heart disease (CHD) represents nearly 1% of live births and complex types are commonly diagnosed during the second trimester of pregnancy. The uncertainty related to a diagnosis of fetal CHD can have long-lasting effects on parental mental health ranging from anxiety and depressive symptoms to psychiatric disorders such as major depression and post-traumatic stress disorder. Recent data have outlined the deleterious impact of prenatal maternal stress on fetal brain development and neurodevelopmental outcomes in infancy regardless of a specific congenital anomaly. Specifically, infants with CHD are reported to have neurodevelopmental impairments in several domains such as motor, language and executive function skills with various degrees of severity. Neurological sequelae of complex CHD results from cumulative risk factors, including fetal cerebral hypoxia/hypoperfusion, surgical interventions, and socioeconomic status. Prenatal parental psychological distress may be a critical and potentially modifiable risk factor (i.e., amenable to prevention or remediation) for adverse neurodevelopmental outcomes in complex CHD. This current review presents existing knowledge on parental mental health and its relationship with neurological and developmental consequences in children with and without CHD. It will further outline future research strategies to enhance children with CHD long-term neurodevelopmental outcomes.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>This review presents current knowledge on the interplay between prenatal parental mental health and neurodevelopmental outcomes of children with complex congenital heart disease (CHD).</p> </ItemContent> <ItemContent> <p>It emphasizes prenatal psychological distress as a modifiable risk factor, highlighting opportunities for early preventive interventions.</p> </ItemContent> <ItemContent> <p>It advocates for future research aiming at improving long-term neurodevelopmental trajectories, moving beyond descriptive associations to concrete strategies for clinical practice and public policy.</p> </ItemContent> </UnorderedList></p>

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Prenatal parental mental health and neurodevelopment in children with congenital heart disease

  • 期刊论文

  • 发表日期：

    2026年5月12日

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  • Johanna Calderon,
  • Sylvie Martins,
  • Julie Deninotti,
  • Neil Derridj,
  • Marilyne Levy,
  • Bertrand Stos,
  • Beatrice Desnous,
  • Lisa Viton-Le-Mao,
  • Marie Vincenti,
  • Sophie Guillaumont,
  • Pascal Amedro,
  • Julie Chabaneix,
  • Daniela Laux,
  • Damien Bonnet

摘要

Abstract

Congenital heart disease (CHD) represents nearly 1% of live births and complex types are commonly diagnosed during the second trimester of pregnancy. The uncertainty related to a diagnosis of fetal CHD can have long-lasting effects on parental mental health ranging from anxiety and depressive symptoms to psychiatric disorders such as major depression and post-traumatic stress disorder. Recent data have outlined the deleterious impact of prenatal maternal stress on fetal brain development and neurodevelopmental outcomes in infancy regardless of a specific congenital anomaly. Specifically, infants with CHD are reported to have neurodevelopmental impairments in several domains such as motor, language and executive function skills with various degrees of severity. Neurological sequelae of complex CHD results from cumulative risk factors, including fetal cerebral hypoxia/hypoperfusion, surgical interventions, and socioeconomic status. Prenatal parental psychological distress may be a critical and potentially modifiable risk factor (i.e., amenable to prevention or remediation) for adverse neurodevelopmental outcomes in complex CHD. This current review presents existing knowledge on parental mental health and its relationship with neurological and developmental consequences in children with and without CHD. It will further outline future research strategies to enhance children with CHD long-term neurodevelopmental outcomes.

Impact

This review presents current knowledge on the interplay between prenatal parental mental health and neurodevelopmental outcomes of children with complex congenital heart disease (CHD).

It emphasizes prenatal psychological distress as a modifiable risk factor, highlighting opportunities for early preventive interventions.

It advocates for future research aiming at improving long-term neurodevelopmental trajectories, moving beyond descriptive associations to concrete strategies for clinical practice and public policy.