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Background <p>The goal of this study was to identify symptoms that occur in children post-SARS-CoV-2 infection, their trajectory over the first-year post-enrollment, and relationship to age.</p> Methods <p>Longitudinal comparison of infected and uninfected cohorts. Participants (0–21 years) with laboratory-confirmed SARS-CoV-2 infection were enrolled as infected. The uninfected cohort was individuals without laboratory evidence of SARS-CoV-2 infection. Primary outcome was presence or absence of symptoms.</p> Results <p>852 participants (705 infected, 147 uninfected) completed baseline visits. Of those, 558 infected subjects completed a 12-month post-enrollment visit. Twenty symptoms were identified as more common in infected participants compared to uninfected, at either baseline or 12-months, with symptoms varying by age. Some symptoms in the infected were more frequent at baseline (e.g. fever, weight loss), whereas many symptoms persisted through 12-months. Several symptoms were more frequent at 12-months (e.g. dysmenorrhea, persistent headache). Presence of symptoms at 12-months was not significantly associated with the wave of circulating virus at original infection.</p> Conclusions <p>Interim analysis at one-year post-enrollment identifies 20 symptoms that infected participants were more likely to report post SARS-CoV-2 infection compared to uninfected, at either visit. Type of symptoms varies by age. Ongoing longitudinal data up to 3-years post-enrollment will increase understanding of long-term symptoms of SARS-CoV-2 infection in children and their trajectory.</p> Clinical trial registration <p>NCT04830852.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Although most children recover fully from SARS-CoV-2 infection, some children experience a variety of prolonged symptoms following infection. Many studies attempting to characterize these symptoms and trajectory are not prospective nor longitudinal and lack comparison to uninfected controls.</p> </ItemContent> <ItemContent> <p>This longitudinal analysis identifies and characterizes post-COVID symptoms in children and adolescents and their trajectory through the first-year post enrollment compared to an uninfected cohort.</p> </ItemContent> <ItemContent> <p>20 post-infection symptoms were identified as occurring more frequently in the infected as compared to uninfected cohort.</p> </ItemContent> <ItemContent> <p>Age played a critical role in the type and frequency of symptoms after SARS-CoV-2 infection. Gastrointestinal symptoms were prominent.</p> </ItemContent> </UnorderedList></p>

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Pediatric SARS-CoV-2 outcomes study (PECOS): 12-month longitudinal analysis of post-COVID symptoms in infected versus uninfected participants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月2日

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  • Gina A. Montealegre Sanchez,
  • Alexandra B. Yonts,
  • Allyson Mateja,
  • Lauren E. Arrigoni,
  • Max T. Wolff,
  • Mallory C. Barrix,
  • Shera Weyers,
  • Maureen A. Edu,
  • Rachel L. Falik,
  • Monika L. Geslak,
  • Marcin Gierdalski,
  • Saira R. Huq,
  • Luigi D. Notarangelo,
  • James E. Bost,
  • C. Jason Liang,
  • Karyl Barron,
  • Roberta L. DeBiasi,
  • Dorothy J. Bulas,
  • Ashraf S. Harahsheh,
  • Craig A. Sable,
  • Yue-Hin Loke,
  • Anastasios C. Koumbourlis,
  • Dinesh K. Pillai,
  • Arthur Ko,
  • Maureen Monaghan,
  • Eric Vilain,
  • Laura J. Olivieri,
  • Linda J. Herbert,
  • Jonathan Zember,
  • Austin A. Dixon,
  • Miciah Wilkerson,
  • Noor Atari,
  • Michael DiMaggio,
  • Tori B. Scott,
  • Lauren St. Louis,
  • Sarah Kollar,
  • Jacob S. White,
  • Bema Boateng,
  • Anta S. Ndour,
  • Corrine Hall,
  • Uyen T. Truong,
  • Stephanie R. Lacey,
  • Kayla P. Carlyle,
  • Mark L. Batshaw,
  • Meghan Delaney,
  • David L. Wessel,
  • Ella Gilligan,
  • Abigail Williams,
  • Casey Yarbrough,
  • Tom R. Burklow,
  • Sanchita Das,
  • Robin L. Dewar,
  • Patricia Bandettini,
  • Marcus Chen,
  • Eric Chu,
  • Ottavia M. Delmonte,
  • Andrew J. Lipton,
  • Kevin B. Rubenstein,
  • Vandana Sachdev,
  • Evrim B. Turkbey,
  • Audrey E. Thurm,
  • Catherine A. Rehm

摘要

Background

The goal of this study was to identify symptoms that occur in children post-SARS-CoV-2 infection, their trajectory over the first-year post-enrollment, and relationship to age.

Methods

Longitudinal comparison of infected and uninfected cohorts. Participants (0–21 years) with laboratory-confirmed SARS-CoV-2 infection were enrolled as infected. The uninfected cohort was individuals without laboratory evidence of SARS-CoV-2 infection. Primary outcome was presence or absence of symptoms.

Results

852 participants (705 infected, 147 uninfected) completed baseline visits. Of those, 558 infected subjects completed a 12-month post-enrollment visit. Twenty symptoms were identified as more common in infected participants compared to uninfected, at either baseline or 12-months, with symptoms varying by age. Some symptoms in the infected were more frequent at baseline (e.g. fever, weight loss), whereas many symptoms persisted through 12-months. Several symptoms were more frequent at 12-months (e.g. dysmenorrhea, persistent headache). Presence of symptoms at 12-months was not significantly associated with the wave of circulating virus at original infection.

Conclusions

Interim analysis at one-year post-enrollment identifies 20 symptoms that infected participants were more likely to report post SARS-CoV-2 infection compared to uninfected, at either visit. Type of symptoms varies by age. Ongoing longitudinal data up to 3-years post-enrollment will increase understanding of long-term symptoms of SARS-CoV-2 infection in children and their trajectory.

Clinical trial registration

NCT04830852.

Impact

Although most children recover fully from SARS-CoV-2 infection, some children experience a variety of prolonged symptoms following infection. Many studies attempting to characterize these symptoms and trajectory are not prospective nor longitudinal and lack comparison to uninfected controls.

This longitudinal analysis identifies and characterizes post-COVID symptoms in children and adolescents and their trajectory through the first-year post enrollment compared to an uninfected cohort.

20 post-infection symptoms were identified as occurring more frequently in the infected as compared to uninfected cohort.

Age played a critical role in the type and frequency of symptoms after SARS-CoV-2 infection. Gastrointestinal symptoms were prominent.