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Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Vitamin K supports neurodevelopment through sphingolipid regulation critical for myelination and neuronal integrity, anti-inflammatory effects via NF-κB pathway inhibition, and improved maternal glucose metabolism and insulin sensitivity.</p> </ItemContent> <ItemContent> <p>Current prenatal recommendations of vitamin K (70–90 µg/day), based solely on coagulation needs, may be insufficient for optimal brain development. A target of 140 µg/day warrants consideration in future guidelines.</p> </ItemContent> <ItemContent> <p>Routine assessment of vitamin K status in prenatal care offers a safe and low-cost opportunity to support neurodevelopment and reduce developmental inequities at the population level.</p> </ItemContent> </UnorderedList></p>

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Maternal phylloquinone intake and early neurodevelopment: implications for prenatal nutrition

  • 期刊论文

  • 发表日期：

    2026年1月13日

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  • Khaled Saad,
  • Zakaria M. Abdel-Sadek,
  • Eman F. Gad,
  • Ahmad Roshdy Ahmad,
  • Amira Elhoufey,
  • Ahmed Tayeb B. Alanazi,
  • Mohamad-Hani Temsah,
  • Mostafa M. Embaby

摘要

Impact

Vitamin K supports neurodevelopment through sphingolipid regulation critical for myelination and neuronal integrity, anti-inflammatory effects via NF-κB pathway inhibition, and improved maternal glucose metabolism and insulin sensitivity.

Current prenatal recommendations of vitamin K (70–90 µg/day), based solely on coagulation needs, may be insufficient for optimal brain development. A target of 140 µg/day warrants consideration in future guidelines.

Routine assessment of vitamin K status in prenatal care offers a safe and low-cost opportunity to support neurodevelopment and reduce developmental inequities at the population level.