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Background <p>Preterm birth increases the risk of neurodevelopmental impairments, emphasizing the need for early interventions. This study aimed to assess the feasibility and effectiveness of a General Movement (GM)-based intervention on infant neurodevelopment and parental mental health.</p> Method <p>In a prospective, randomized-controlled trial, very preterm infants (gestational age &lt;32 weeks or birth weight &lt;1500 g) were enrolled between October 1, 2021, and June 6, 2023. Infants received a three times daily GM-based treatment by trained parents over 10 weeks starting at 34 weeks PMA or standard care. Primary outcome was neurodevelopment until 2 years’ corrected age, secondary outcomes included parental mental health and serum levels of brain damage biomarkers.</p> Results <p>Sixty-six infants were randomized (32 control, 34 intervention). The median birth weight was 1243 g (IQR, 919-1623 g) in the control group and 1035 g (IQR, 853-1230 g) in the GM group. No significant group differences were observed for neurodevelopment outcome and parental mental health. Interestingly, all three infants displaying poor neuromotor features in the intervention group before treatment showed good neurodevelopment in the follow-up.</p> Conclusion <p>Our findings suggest a potential role of GM-based intervention in high-risk preterm infants. Future research should focus on improved participant selection and adherence.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>A General Movement (GM)-based early intervention starting at 34 weeks PMA, led by parents with telehealth support over 10 weeks from pediatric physiotherapists, was both feasible and well-received.</p> </ItemContent> <ItemContent> <p>Infant neurodevelopment until 2 years’ corrected age and parental mental health were similar in both the intervention and control groups.</p> </ItemContent> <ItemContent> <p>The approach may be especially helpful for preterm infants who show early signs of neurodevelopmental challenges.</p> </ItemContent> <ItemContent> <p>As one of the first studies of its kind, this RCT adds valuable knowledge about GM-based therapy for very preterm infants.</p> </ItemContent> <ItemContent> <p>The results support the importance of personalized early interventions to meet the unique needs of each infant.</p> </ItemContent> </UnorderedList></p>

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General movement based therapy to support neurodevelopment of preterm infants: a randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月9日

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  • Anna Badura,
  • Annika Dietz,
  • Florian Zeman,
  • Sarah Klarner,
  • Luisa Ammon,
  • Maria Waltner-Romen,
  • Elke Griesmaier,
  • Maike Wellmann,
  • Verena Lehnerer,
  • Sven Wellmann

摘要

Background

Preterm birth increases the risk of neurodevelopmental impairments, emphasizing the need for early interventions. This study aimed to assess the feasibility and effectiveness of a General Movement (GM)-based intervention on infant neurodevelopment and parental mental health.

Method

In a prospective, randomized-controlled trial, very preterm infants (gestational age <32 weeks or birth weight <1500 g) were enrolled between October 1, 2021, and June 6, 2023. Infants received a three times daily GM-based treatment by trained parents over 10 weeks starting at 34 weeks PMA or standard care. Primary outcome was neurodevelopment until 2 years’ corrected age, secondary outcomes included parental mental health and serum levels of brain damage biomarkers.

Results

Sixty-six infants were randomized (32 control, 34 intervention). The median birth weight was 1243 g (IQR, 919-1623 g) in the control group and 1035 g (IQR, 853-1230 g) in the GM group. No significant group differences were observed for neurodevelopment outcome and parental mental health. Interestingly, all three infants displaying poor neuromotor features in the intervention group before treatment showed good neurodevelopment in the follow-up.

Conclusion

Our findings suggest a potential role of GM-based intervention in high-risk preterm infants. Future research should focus on improved participant selection and adherence.

Impact

A General Movement (GM)-based early intervention starting at 34 weeks PMA, led by parents with telehealth support over 10 weeks from pediatric physiotherapists, was both feasible and well-received.

Infant neurodevelopment until 2 years’ corrected age and parental mental health were similar in both the intervention and control groups.

The approach may be especially helpful for preterm infants who show early signs of neurodevelopmental challenges.

As one of the first studies of its kind, this RCT adds valuable knowledge about GM-based therapy for very preterm infants.

The results support the importance of personalized early interventions to meet the unique needs of each infant.