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Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Childhood-onset Takayasu arteritis (cTAK) is not a uniform disease but exhibits distinct age-specific clinical and vascular phenotypes across developmental stages, from infants to adolescents.</p> </ItemContent> <ItemContent> <p>These differences necessitate age-tailored diagnostic approaches and therapeutic strategies to improve outcomes and reduce treatment-related morbidity.</p> </ItemContent> <ItemContent> <p>The concept of “developmental vasculopathy” links vascular involvement patterns to maturational changes in the arterial wall, addressing critical diagnostic challenges in differentiating incomplete Kawasaki disease from cTAK.</p> </ItemContent> <ItemContent> <p>The progression toward age-stratified management patterns heralds a new era of personalized medicine in cTAK, with precision diagnostics and tailored interventions to improve outcomes for this serious childhood disease.</p> </ItemContent> </UnorderedList></p>

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Advancing the understanding of age-specific phenotypes in childhood-onset takayasu arteritis

  • 期刊论文

  • 发表日期：

    2025年11月19日

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  • Khaled Saad,
  • Soha A. Hussain,
  • Ahmad Roshdy Ahmad,
  • Mohamed Shawky Elfarargy,
  • Amira Elhoufey,
  • Khalid A. Alhasan,
  • Mohamad-Hani Temsah,
  • Mostafa M. Embaby

摘要

Impact

Childhood-onset Takayasu arteritis (cTAK) is not a uniform disease but exhibits distinct age-specific clinical and vascular phenotypes across developmental stages, from infants to adolescents.

These differences necessitate age-tailored diagnostic approaches and therapeutic strategies to improve outcomes and reduce treatment-related morbidity.

The concept of “developmental vasculopathy” links vascular involvement patterns to maturational changes in the arterial wall, addressing critical diagnostic challenges in differentiating incomplete Kawasaki disease from cTAK.

The progression toward age-stratified management patterns heralds a new era of personalized medicine in cTAK, with precision diagnostics and tailored interventions to improve outcomes for this serious childhood disease.