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Background <p>Necrotising enterocolitis (NEC) is a significant complication for very preterm infants (VPIs). The role of genetic predisposition in the development of NEC among VPIs has not been firmly established. This study aimed to explore the heritability factors in NEC among VPIs.</p> Methods <p>A retrospective cohort study was conducted on 4138 infants from 2069 twin pairs. Twins were categorised based on chorionicity.Chi-square analyses were conducted to compare the incidence of NEC between monochorionic and dichorionic twin pairs. The Pearson chi-square test and ACE modelling appropriate for analysing twin cohorts were utilised. Stratified analyses were conducted for early-onset and late-onset NEC, surgical NEC, and NEC in different gestational age groups.</p> Results <p>The overall incidence of NEC was 5%. No significant difference was observed between monochorionic and dichorionic twins. ACE modelling revealed no contribution of heritability to NEC risk (% <i>A</i> = 0.00%, 95% CI [0.00%, 0.07%]). Stratified analyses for early-onset and late-onset NEC, surgical NEC, and NEC in different gestational age groups (GA &lt; 28 weeks and 28<sup>+0</sup>–31<sup>+6</sup> weeks) also revealed no significant heritability.</p> Conclusion <p>Our findings suggest that, under the current conditions of medical practice, heritability does not play a major role in the development of NEC.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>NEC is a significant and potentially life-threatening complication in very preterm infants (VPIs). Previous studies have suggested a potential genetic susceptibility to NEC, although the evidence has been inconsistent.</p> </ItemContent> <ItemContent> <p>Genetic heritability does not play a major role in the development of NEC. Stratified analyses for early-onset and late-onset NEC, surgical NEC, and different gestational age groups also confirmed the lack of significant genetic influence.</p> </ItemContent> <ItemContent> <p>Our findings suggest that attention should be given to the risk factors contributing to the occurrence of NEC and that efforts should be made to improve the level of clinical treatment.</p> </ItemContent> </UnorderedList></p>

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Genetic susceptibility to necrotizing enterocolitis in very preterm infants: evidence from twin data

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • Ruimiao Bai,
  • Xiang Chen,
  • Siyuan Jiang,
  • Yan Mo,
  • Aimin Qian,
  • Yun Cao,
  • Lizhong Du,
  • Shoo Kim Lee,
  • LiYuan Hu,
  • Jie Yang,
  • Yajun Li,
  • Xiaoping Lei,
  • Lijuan Luo,
  • Wenhao Zhou,
  • Shoo K. Lee,
  • Chao Chen,
  • Li-Zhong Du,
  • Wen-Hao Zhou,
  • Yun Cao,
  • Xiu-Yong Chen,
  • Hu-Yan Zhang,
  • Xiu-Ying Tian,
  • Jing-Yun Shi,
  • Zhan-Kui Li,
  • Chuan-Zhong Yang,
  • Ling Liu,
  • Zu-Ming Yang,
  • Jian-Hua Fu,
  • Yong Ji,
  • Dong-Mei Chen,
  • Chang-Yi Yang,
  • Rui Chen,
  • Xiao-Ming Peng,
  • Ruo-Bing Shan,
  • Shu-Ping Han,
  • Hui Wu,
  • Li-Li Wang,
  • Qiu-Fen Wei,
  • Ming-Xia Li,
  • Yi-Heng Dai,
  • Hong Jiang,
  • Wen-Qing Kang,
  • Xiao-Hui Gong,
  • Xiao-Yun Zhong,
  • Yuan Shi,
  • Shan-Yu Jiang,
  • Bing Sun,
  • Long Li,
  • Zhen-Lang Lin,
  • Jiang-Qin Liu,
  • Jia-Hua Pan,
  • Hong-Ping Xia,
  • Xiao-Ying Li,
  • Fa-Lin Xu,
  • Yin-Ping Qiu,
  • Li Ma,
  • Ling Yang,
  • Xiao-Ri He,
  • Yan-Hong Li,
  • De-Yi Zhuang,
  • Qin Zhang,
  • Wen-Bin Dong,
  • Jian-Hua Sun,
  • Kun Liang,
  • Huai-Yan Wang,
  • Jin-Xing Feng,
  • Li-Ping Chen,
  • Xin-Zhu Lin,
  • Chun-Ming Jiang,
  • Chu-An Nie,
  • Lin-Kong Zeng,
  • Ming-Yan Hei,
  • Hong-Dan Zhu,
  • Hong-Ying Mi,
  • Zhao-Qing Yin,
  • Hong-Xia Song,
  • Hong-Yun Wang,
  • Dong Li,
  • Yan Gao,
  • Ya-Juan Wang,
  • Li-Ying Dai,
  • Li-Yan Zhang,
  • Yang-Fang Li,
  • Qian-Shen Zhang,
  • Guo-Fang Ding,
  • Ji-Mei Wang,
  • Xiao-Xia Chen,
  • Zhen Wang,
  • Zheng Tang,
  • Xiao-Lu Ma,
  • Xiao-Mei Zhang,
  • Xiao-Lan Zhang,
  • Fang Wu,
  • Yan-Xiang Chen,
  • Ying Wu,
  • Joseph Ting

摘要

Background

Necrotising enterocolitis (NEC) is a significant complication for very preterm infants (VPIs). The role of genetic predisposition in the development of NEC among VPIs has not been firmly established. This study aimed to explore the heritability factors in NEC among VPIs.

Methods

A retrospective cohort study was conducted on 4138 infants from 2069 twin pairs. Twins were categorised based on chorionicity.Chi-square analyses were conducted to compare the incidence of NEC between monochorionic and dichorionic twin pairs. The Pearson chi-square test and ACE modelling appropriate for analysing twin cohorts were utilised. Stratified analyses were conducted for early-onset and late-onset NEC, surgical NEC, and NEC in different gestational age groups.

Results

The overall incidence of NEC was 5%. No significant difference was observed between monochorionic and dichorionic twins. ACE modelling revealed no contribution of heritability to NEC risk (% A = 0.00%, 95% CI [0.00%, 0.07%]). Stratified analyses for early-onset and late-onset NEC, surgical NEC, and NEC in different gestational age groups (GA < 28 weeks and 28+0–31+6 weeks) also revealed no significant heritability.

Conclusion

Our findings suggest that, under the current conditions of medical practice, heritability does not play a major role in the development of NEC.

Impact

NEC is a significant and potentially life-threatening complication in very preterm infants (VPIs). Previous studies have suggested a potential genetic susceptibility to NEC, although the evidence has been inconsistent.

Genetic heritability does not play a major role in the development of NEC. Stratified analyses for early-onset and late-onset NEC, surgical NEC, and different gestational age groups also confirmed the lack of significant genetic influence.

Our findings suggest that attention should be given to the risk factors contributing to the occurrence of NEC and that efforts should be made to improve the level of clinical treatment.