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Background <p>To investigate the prevalence of Celiac disease (CeD) in children and adolescents with SLE.</p> Methods <p>We completed a retrospective cohort study of children and adolescents with childhood-onset SLE (cSLE). We included patients who underwent CeD screening with tissue transglutaminase immunoglobulin A (tTG-IgA) serology within a year of cSLE diagnosis. Clinical and laboratory data were extracted from a dedicated lupus database, supplemented by chart review. CeD diagnosis was confirmed by duodenal histology. We calculated the prevalence of positive CeD serology, biopsy-confirmed CeD and CeD clinical features, and compared SLE features between CeD and non-CeD patients with Fisher’s exact tests.</p> Results <p>Three hundred children with SLE underwent CeD screening. Thirteen (4%) had positive tTG-IgA serology. Of those, ten (77%) underwent endoscopy and eight had histopathologic evidence of CeD (3% of cSLE cohort). Among patients with biopsy confirmed CeD, only 50% had gastrointestinal symptoms. There was no difference in prevalence of cSLE features between those with and without CeD.</p> Conclusion <p>Biopsy-confirmed CeD was three times prevalent in children and adolescents with cSLE than reported in the general pediatric population. Only half of cSLE patients with CeD had gastrointestinal symptoms, highlighting the importance of screening in the cSLE population.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>The incidence of celiac disease has increased over the past decades, particularly in people with comorbid autoimmune diseases.</p> </ItemContent> <ItemContent> <p>Celiac disease is three times more prevalent among children with systemic lupus erythematosus compared to the general pediatric population.</p> </ItemContent> <ItemContent> <p>Half of childhood-onset SLE patients with biopsy confirmed celiac disease were asymptomatic, highlighting the importance of routine CeD screening in the cSLE population.</p> </ItemContent> </UnorderedList></p>

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Celiac disease is more prevalent among children and adolescents with systemic lupus erythematosus

  • 期刊论文

  • 发表日期：

    2025年10月15日

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  • Oscar Mwizerwa,
  • Andrea M. Knight,
  • Daniela Dominguez,
  • Deborah Levy,
  • Holly Convery,
  • Kendal Thompson,
  • Nicholas Gold,
  • Catharine M. Walsh,
  • Linda T. Hiraki

摘要

Background

To investigate the prevalence of Celiac disease (CeD) in children and adolescents with SLE.

Methods

We completed a retrospective cohort study of children and adolescents with childhood-onset SLE (cSLE). We included patients who underwent CeD screening with tissue transglutaminase immunoglobulin A (tTG-IgA) serology within a year of cSLE diagnosis. Clinical and laboratory data were extracted from a dedicated lupus database, supplemented by chart review. CeD diagnosis was confirmed by duodenal histology. We calculated the prevalence of positive CeD serology, biopsy-confirmed CeD and CeD clinical features, and compared SLE features between CeD and non-CeD patients with Fisher’s exact tests.

Results

Three hundred children with SLE underwent CeD screening. Thirteen (4%) had positive tTG-IgA serology. Of those, ten (77%) underwent endoscopy and eight had histopathologic evidence of CeD (3% of cSLE cohort). Among patients with biopsy confirmed CeD, only 50% had gastrointestinal symptoms. There was no difference in prevalence of cSLE features between those with and without CeD.

Conclusion

Biopsy-confirmed CeD was three times prevalent in children and adolescents with cSLE than reported in the general pediatric population. Only half of cSLE patients with CeD had gastrointestinal symptoms, highlighting the importance of screening in the cSLE population.

Impact

The incidence of celiac disease has increased over the past decades, particularly in people with comorbid autoimmune diseases.

Celiac disease is three times more prevalent among children with systemic lupus erythematosus compared to the general pediatric population.

Half of childhood-onset SLE patients with biopsy confirmed celiac disease were asymptomatic, highlighting the importance of routine CeD screening in the cSLE population.