Scholarlink

Background <p>This study developed and validated a continuous metabolic syndrome (MetS) risk score (msRS) for adolescents and evaluated its clinical utility in identifying multiple clinical cardiovascular markers (CCMs) using dual adolescent populations.</p> Methods <p>Adolescents aged 12‒18 from two stratified random samples were used: the nationwide Nutrition and Health Survey in Taiwan (NAHSIT, <i>n</i> = 1920) for development and the Adiposity‒Cardiovascular Disease Axis study in Southern Taiwan (adiCards, <i>n</i> = 3295) for validation. Four sex-and-age-specific msRS were developed through confirmatory factor analysis (CFA) utilizing five MetS components—waist circumference, high-density lipoprotein cholesterol, triglycerides, fasting glucose, and mean arterial pressure. Their discriminatory ability for clinical outcomes was validated using the area under receiver operating characteristic (AU-ROC) curve.</p> Results <p>The msRS demonstrated exceptional capability in detecting MetS in NAHSIT and adiCards cohorts (AU-ROCs:&#xa0;0.954‒0.969). Adjusted for covariates, msRS explained higher variability in body-fat percentage, apolipoproteins B/A1, and homeostatic model assessment of insulin resistance (HOMA-IR) than binary MetS and abnormal components count (partial <i>R</i><sup>2</sup>, 23.7‒26.8% vs 4.1‒20.7%) in the validation dataset. An increase in msRS was associated with a 1.9-, 2.7-, 3.4-, and 14.4-fold risk of elevated low-density lipoprotein cholesterol, hyperuricemia, high HOMA-IR, and ≥3 CCMs.</p> Conclusion <p>The CFA-derived sex-and-age-adjusted msRS scheme provides an improving measure to assess and manage adolescent cardiometabolic health.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Adolescent MetS components share a latent metabolic construct.</p> </ItemContent> <ItemContent> <p>A scoring system through confirmatory factor analysis captures sex-and-age specific metabolic heterogeneity.</p> </ItemContent> <ItemContent> <p>Continuous risk score accurately discriminates pediatric MetS.</p> </ItemContent> <ItemContent> <p>MetS risk score effectively detects pediatric cardiovascular risk.</p> </ItemContent> <ItemContent> <p>Consideration of population characteristics is essential when developing a continuous MetS score.</p> </ItemContent> </UnorderedList></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Confirmatory-factor-analysis-derived metabolic syndrome risk score: development, validation, and clinical utility in dual adolescent populations

  • 期刊论文

  • 发表日期：

    2025年9月20日

查看全文
  • Yu-Ting Chin,
  • Pei-Wen Wu,
  • Pin-Rui Huang,
  • Sharon Tsai,
  • Wei-Ting Lin,
  • Chun-Ying Lee,
  • Wei-Chung Tsai,
  • Chien-Hung Lee

摘要

Background

This study developed and validated a continuous metabolic syndrome (MetS) risk score (msRS) for adolescents and evaluated its clinical utility in identifying multiple clinical cardiovascular markers (CCMs) using dual adolescent populations.

Methods

Adolescents aged 12‒18 from two stratified random samples were used: the nationwide Nutrition and Health Survey in Taiwan (NAHSIT, n = 1920) for development and the Adiposity‒Cardiovascular Disease Axis study in Southern Taiwan (adiCards, n = 3295) for validation. Four sex-and-age-specific msRS were developed through confirmatory factor analysis (CFA) utilizing five MetS components—waist circumference, high-density lipoprotein cholesterol, triglycerides, fasting glucose, and mean arterial pressure. Their discriminatory ability for clinical outcomes was validated using the area under receiver operating characteristic (AU-ROC) curve.

Results

The msRS demonstrated exceptional capability in detecting MetS in NAHSIT and adiCards cohorts (AU-ROCs: 0.954‒0.969). Adjusted for covariates, msRS explained higher variability in body-fat percentage, apolipoproteins B/A1, and homeostatic model assessment of insulin resistance (HOMA-IR) than binary MetS and abnormal components count (partial R2, 23.7‒26.8% vs 4.1‒20.7%) in the validation dataset. An increase in msRS was associated with a 1.9-, 2.7-, 3.4-, and 14.4-fold risk of elevated low-density lipoprotein cholesterol, hyperuricemia, high HOMA-IR, and ≥3 CCMs.

Conclusion

The CFA-derived sex-and-age-adjusted msRS scheme provides an improving measure to assess and manage adolescent cardiometabolic health.

Impact

Adolescent MetS components share a latent metabolic construct.

A scoring system through confirmatory factor analysis captures sex-and-age specific metabolic heterogeneity.

Continuous risk score accurately discriminates pediatric MetS.

MetS risk score effectively detects pediatric cardiovascular risk.

Consideration of population characteristics is essential when developing a continuous MetS score.