Background Body fat distribution patterns impact adolescent health, yet research on dietary lignans’ influence remains limited. This study investigated their association among U.S. adolescents. Methods Data from 1579 adolescents (NHANES 2003–2006) were analyzed. Urinary enterolactone and enterodiol concentrations measured dietary lignan intake. Dual-energy X-ray absorptiometry assessed body fat distribution. Survey-weighted linear regression models with progressive adjustment were employed, and restricted cubic spline analyses evaluated potential non-linear relationships. Results Urinary enterolactone levels were significantly inversely associated with android-to-gynoid fat ratio (fully adjusted model: β = −0.007, 95% CI: −0.012, −0.002, P = 0.008), indicating a significant negative relationship between enterolactone and android-to-gynoid fat ratio, with restricted cubic spline analysis confirming significant overall association (P for overall = 0.001, demonstrating the statistical significance of the entire relationship) and linear relationship (P for nonlinear = 0.064, indicating the relationship does not significantly deviate from linearity). Further analysis showed that enterodiol was positively associated with gynoid fat ratio (β = 0.360, 95% CI: 0.043, 0.677, P = 0.028), suggesting enterodiol exposure may favor gynoid fat distribution. Conclusion Dietary lignan intake significantly associates with more favorable body fat distribution patterns among U.S. adolescents, suggesting that increasing dietary lignan intake may be a potential strategy for improving adolescent body composition. Impact <UnorderedList Mark="Bullet"> <ItemContent> Dietary lignan intake, measured by urinary biomarkers, is significantly associated with favorable body fat distribution patterns in U.S. adolescents. </ItemContent> <ItemContent> This study highlights the role of dietary lignans, an underexplored dietary component, in influencing body fat distribution during adolescence, expanding on prior research focused on adults. </ItemContent> <ItemContent> These findings suggest dietary lignans as a potential nutritional strategy to improve body fat distribution in adolescents, offering insights for public health interventions targeting metabolic health in youth. </ItemContent> </UnorderedList>

Dietary lignan intake and body fat distribution in U.S. adolescents

期刊论文
发表日期：

2025年9月10日

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Xuejie Gao,
Fengxiu Chen,
Shiyi Xu,
Weijie Ou,
Hong Ye,
Yuyun Chen

摘要

Background

Body fat distribution patterns impact adolescent health, yet research on dietary lignans’ influence remains limited. This study investigated their association among U.S. adolescents.

Methods

Data from 1579 adolescents (NHANES 2003–2006) were analyzed. Urinary enterolactone and enterodiol concentrations measured dietary lignan intake. Dual-energy X-ray absorptiometry assessed body fat distribution. Survey-weighted linear regression models with progressive adjustment were employed, and restricted cubic spline analyses evaluated potential non-linear relationships.

Results

Urinary enterolactone levels were significantly inversely associated with android-to-gynoid fat ratio (fully adjusted model: β = −0.007, 95% CI: −0.012, −0.002, P = 0.008), indicating a significant negative relationship between enterolactone and android-to-gynoid fat ratio, with restricted cubic spline analysis confirming significant overall association (P for overall = 0.001, demonstrating the statistical significance of the entire relationship) and linear relationship (P for nonlinear = 0.064, indicating the relationship does not significantly deviate from linearity). Further analysis showed that enterodiol was positively associated with gynoid fat ratio (β = 0.360, 95% CI: 0.043, 0.677, P = 0.028), suggesting enterodiol exposure may favor gynoid fat distribution.

Conclusion

Dietary lignan intake significantly associates with more favorable body fat distribution patterns among U.S. adolescents, suggesting that increasing dietary lignan intake may be a potential strategy for improving adolescent body composition.

Impact

Dietary lignan intake, measured by urinary biomarkers, is significantly associated with favorable body fat distribution patterns in U.S. adolescents.

This study highlights the role of dietary lignans, an underexplored dietary component, in influencing body fat distribution during adolescence, expanding on prior research focused on adults.

These findings suggest dietary lignans as a potential nutritional strategy to improve body fat distribution in adolescents, offering insights for public health interventions targeting metabolic health in youth.