Scholarlink

Background <p>Risk factors for cardiometabolic disease may have fetal origins, but the biological pathways linking gestational conditions to these risk factors are only partially understood.</p> Methods <p>Among 145 Cincinnati-based HOME Study mother-child dyads, we detected 14,384 cord serum metabolic features using liquid chromatography high-resolution mass spectrometry. We measured cardiometabolic risk factors, including visceral fat, serum triglyceride, high-density lipoprotein cholesterol (HDL), leptin, adiponectin, insulin concentration, glucose, and systolic blood pressure (SBP) at age 12 years. Using sparse Partial Least Squares Regression (sPLS-R), we simultaneously modeled the association of metabolic features with all 8 risk factors. We prioritized features with the highest sPLS-R-derived CM risk factor correlations for metabolic pathway enrichment analysis.</p> Results <p>We identified two groups of cardiometabolic risk factors in adolescents maximally associated with neonatal metabolic features. The first was visceral fat, triglycerides, HDL, insulin, and leptin; the second was glucose and SBP. The 178 metabolic features with the highest sPLS-R-derived feature-outcome correlations were enriched in 31 pathways related to short-chain fatty acid, vitamins C and B3, and amino acid metabolism, as well as glycolysis and gluconeogenesis.</p> Conclusions <p>We identified 31 pathways that may help elucidate underlying mechanisms between fetal environmental stressors and the development of cardiometabolic risk factors.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Using non-targeted metabolomics, we identified neonatal metabolic features linked to two groups of cardiometabolic risk factors in adolescents, suggesting distinct early-life CM risk trajectories and adolescent subphenotypes.</p> </ItemContent> <ItemContent> <p>One cardiometabolic group was characterized by higher visceral fat, triglycerides, insulin, leptin, as well as lower HDL; the other group was related to elevated glucose and systolic blood pressure.</p> </ItemContent> <ItemContent> <p>Using a variable selection and data-dimension reduction technique, these two groups were associated with 178 metabolic features and 31 biological pathways related to short-chain fatty acid, vitamins C and B3, and amino acid metabolism, as well as glycolysis and gluconeogenesis.</p> </ItemContent> </UnorderedList></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors

  • 期刊论文

  • 发表日期：

    2025年8月16日

查看全文
  • Elvira S. Fleury,
  • George D. Papandonatos,
  • Katherine E. Manz,
  • Kurt Pennell,
  • Amber M. Hall,
  • Aimin Chen,
  • Jessie P. Buckley,
  • Kimberly Yolton,
  • Kim M. Cecil,
  • Bruce P. Lanphear,
  • Charles B. Eaton,
  • Douglas I. Walker,
  • Joseph M. Braun

摘要

Background

Risk factors for cardiometabolic disease may have fetal origins, but the biological pathways linking gestational conditions to these risk factors are only partially understood.

Methods

Among 145 Cincinnati-based HOME Study mother-child dyads, we detected 14,384 cord serum metabolic features using liquid chromatography high-resolution mass spectrometry. We measured cardiometabolic risk factors, including visceral fat, serum triglyceride, high-density lipoprotein cholesterol (HDL), leptin, adiponectin, insulin concentration, glucose, and systolic blood pressure (SBP) at age 12 years. Using sparse Partial Least Squares Regression (sPLS-R), we simultaneously modeled the association of metabolic features with all 8 risk factors. We prioritized features with the highest sPLS-R-derived CM risk factor correlations for metabolic pathway enrichment analysis.

Results

We identified two groups of cardiometabolic risk factors in adolescents maximally associated with neonatal metabolic features. The first was visceral fat, triglycerides, HDL, insulin, and leptin; the second was glucose and SBP. The 178 metabolic features with the highest sPLS-R-derived feature-outcome correlations were enriched in 31 pathways related to short-chain fatty acid, vitamins C and B3, and amino acid metabolism, as well as glycolysis and gluconeogenesis.

Conclusions

We identified 31 pathways that may help elucidate underlying mechanisms between fetal environmental stressors and the development of cardiometabolic risk factors.

Impact

Using non-targeted metabolomics, we identified neonatal metabolic features linked to two groups of cardiometabolic risk factors in adolescents, suggesting distinct early-life CM risk trajectories and adolescent subphenotypes.

One cardiometabolic group was characterized by higher visceral fat, triglycerides, insulin, leptin, as well as lower HDL; the other group was related to elevated glucose and systolic blood pressure.

Using a variable selection and data-dimension reduction technique, these two groups were associated with 178 metabolic features and 31 biological pathways related to short-chain fatty acid, vitamins C and B3, and amino acid metabolism, as well as glycolysis and gluconeogenesis.