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Background <p>Therapeutic hypothermia is an intervention that improves outcomes and alters early outcome-prediction in infants with moderate-severe hypoxic-ischemic encephalopathy (HIE). This study evaluated the early predictive accuracy of a fully automated continuous EEG background trend, Brain State of the Newborn (BSN) in a regional Swedish cohort of infants with presumed HIE.</p> Method <p>The BSN trend characterizes 1-min segments of EEG from zero (inactive) to 100 (continuous) and was generated from aEEG/EEG in 85 infants treated with hypothermia. BSN trajectories were compared in relation to clinical grading of encephalopathy and outcome. Receiver operating characteristics were computed for good (no/mild impairment) and poor outcomes (moderate/severe impairment or death).</p> Results <p>During the first 48 h, BSN levels differed significantly between moderate and severe HIE (typical median BSN levels &gt;80 and &lt;40, respectively). The predictive accuracy of BSN was high already at 6 h (AUC 0.84) and at 12 h (AUC 0.91), with corresponding positive predictive values (PPV) &gt; 0.92 for good outcome (cutoff BSN &gt; 80) and PPV &gt; 0.95 for poor outcome (cutoff BSN &lt; 40).</p> Conclusion <p>BSN gives a continuous and objective measure of EEG background activity, which is highly predictive of good and poor outcomes already from the first 6–12 h in hypothermia-treated infants with moderate-severe HIE.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Brain State of the Newborn (BSN) is a deep learning-based EEG trend displaying electrocortical activity as numerical values. Here we establish that BSN trends over the first 48 h differ between infants with moderate versus severe hypoxic-ischemic encephalopathy (HIE) and is highly predictive of long-term outcome.</p> </ItemContent> <ItemContent> <p>This is the first study applying BSN trends in a cohort of exclusively hypothermia-treated infants, demonstrating its value for outcome-prediction already from the first 12 h after birth.</p> </ItemContent> <ItemContent> <p>The BSN provides a continuous bedside evaluation of brain function that complements the visual aEEG/EEG review and can assist bedside assessments in neonatal intensive care units.</p> </ItemContent> </UnorderedList></p>

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Early outcome-prediction with an automated EEG background trend in hypothermia-treated newborns with encephalopathy

  • 期刊论文

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  • 发表日期：

    2025年6月16日

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  • Karla Gonzalez-Tamez,
  • Saeed Montazeri,
  • Johan Ågren,
  • Sampsa Vanhatalo,
  • Lena Hellström-Westas

摘要

Background

Therapeutic hypothermia is an intervention that improves outcomes and alters early outcome-prediction in infants with moderate-severe hypoxic-ischemic encephalopathy (HIE). This study evaluated the early predictive accuracy of a fully automated continuous EEG background trend, Brain State of the Newborn (BSN) in a regional Swedish cohort of infants with presumed HIE.

Method

The BSN trend characterizes 1-min segments of EEG from zero (inactive) to 100 (continuous) and was generated from aEEG/EEG in 85 infants treated with hypothermia. BSN trajectories were compared in relation to clinical grading of encephalopathy and outcome. Receiver operating characteristics were computed for good (no/mild impairment) and poor outcomes (moderate/severe impairment or death).

Results

During the first 48 h, BSN levels differed significantly between moderate and severe HIE (typical median BSN levels >80 and <40, respectively). The predictive accuracy of BSN was high already at 6 h (AUC 0.84) and at 12 h (AUC 0.91), with corresponding positive predictive values (PPV) > 0.92 for good outcome (cutoff BSN > 80) and PPV > 0.95 for poor outcome (cutoff BSN < 40).

Conclusion

BSN gives a continuous and objective measure of EEG background activity, which is highly predictive of good and poor outcomes already from the first 6–12 h in hypothermia-treated infants with moderate-severe HIE.

Impact

Brain State of the Newborn (BSN) is a deep learning-based EEG trend displaying electrocortical activity as numerical values. Here we establish that BSN trends over the first 48 h differ between infants with moderate versus severe hypoxic-ischemic encephalopathy (HIE) and is highly predictive of long-term outcome.

This is the first study applying BSN trends in a cohort of exclusively hypothermia-treated infants, demonstrating its value for outcome-prediction already from the first 12 h after birth.

The BSN provides a continuous bedside evaluation of brain function that complements the visual aEEG/EEG review and can assist bedside assessments in neonatal intensive care units.