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Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Children with short bowel syndrome depend on parenteral nutrition, which carries significant risks.</p> </ItemContent> <ItemContent> <p>Short bowel syndrome patients show reduced gut microbial diversity, increased inflammation-associated bacteria, and fewer beneficial bacteria.</p> </ItemContent> <ItemContent> <p>This is the first systematic review and meta-analysis examining the gut microbiome in children with short bowel syndrome.</p> </ItemContent> <ItemContent> <p>The review demonstrated significantly lower bacterial diversity and richness in children with short bowel syndrome, regardless of achievement of intestinal autonomy. Diversity and richness were greater in children who achieved intestinal autonomy than those on parenteral nutrition, though not statistically significant.</p> </ItemContent> <ItemContent> <p>Larger studies adjusting for confounding factors may identify future therapeutic strategies.</p> </ItemContent> </UnorderedList></p>

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Gut microbiome in paediatric short bowel syndrome: a systematic review and sequencing re-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月7日

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  • Jemma S. Cleminson,
  • Gregory R. Young,
  • David I. Campbell,
  • Fiona Campbell,
  • Andrew R. Gennery,
  • Janet E. Berrington,
  • Christopher J. Stewart

摘要

Impact

Children with short bowel syndrome depend on parenteral nutrition, which carries significant risks.

Short bowel syndrome patients show reduced gut microbial diversity, increased inflammation-associated bacteria, and fewer beneficial bacteria.

This is the first systematic review and meta-analysis examining the gut microbiome in children with short bowel syndrome.

The review demonstrated significantly lower bacterial diversity and richness in children with short bowel syndrome, regardless of achievement of intestinal autonomy. Diversity and richness were greater in children who achieved intestinal autonomy than those on parenteral nutrition, though not statistically significant.

Larger studies adjusting for confounding factors may identify future therapeutic strategies.