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Background <p>This systematic review was designed to assess the efficacy and safety of high-frequency oscillatory ventilation (HFOV) combined with volume guarantee (VG) in infants compared with HFOV alone.</p> Methods <p>We searched for electronic databases to find studies using HFOV-VG or HFOV for respiratory support in infants from the database creation to October 20, 2024. Two evaluators independently screened the literature, extracted data, and evaluated quality. Meta-analysis was performed using Rev man 5.3 software on survival-free BPD at grades 2 and 3 (SF-BPD), the incidence of BPD, mortality, duration of invasive ventilation, length of hospital stays, and complications in both groups.</p> Results <p>The review included 11 studies (three randomized controlled trials, one non-randomized controlled trial, and seven observational studies) with 785 participants. Data analysis showed that HFOV-VG could increase SF-BPD in preterm infants (OR 3.15, 95%CI 1.66–5.98) without reducing the overall incidence of BPD compared with HFOV alone. HFOV-VG may offer advantages in shortening the duration of MV and total hospital stay, potentially reducing mortality and the incidence of air leak syndrome.</p> Conclusions existing <p>Studies showed that HFOV-VG had certain advantages in improving oxygenation and stable ventilation to protect neonatal lungs. HFOV-VG could increase SF-BPD in preterm infants with GA &lt; 32 weeks without reducing the overall incidence of BPD compared with HFOV alone.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Existing evidence suggested that HFOV-VG ventilation strategies could increase SF-BPD in preterm infants with GA &lt; 32 weeks without reducing the overall incidence of BPD compared with HFOV alone.</p> </ItemContent> <ItemContent> <p>HFOV-VG ventilation strategy has certain advantages in improving oxygenation and stable ventilation to protect neonatal lungs.</p> </ItemContent> <ItemContent> <p>The effects of HFOV-VG <i>vs</i>. HFOV in neonates remain to be further validated by additional large sample, multicenter RCTs.</p> </ItemContent> </UnorderedList></p>

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High-frequency oscillatory ventilation with volume guarantee in infants: a systematic review

  • 期刊论文

  • 发表日期：

    2025年3月20日

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  • Wanjiao Liu,
  • Haifeng Zong,
  • Jin Jiang,
  • Chuanzhong Yang,
  • Fang Li

摘要

Background

This systematic review was designed to assess the efficacy and safety of high-frequency oscillatory ventilation (HFOV) combined with volume guarantee (VG) in infants compared with HFOV alone.

Methods

We searched for electronic databases to find studies using HFOV-VG or HFOV for respiratory support in infants from the database creation to October 20, 2024. Two evaluators independently screened the literature, extracted data, and evaluated quality. Meta-analysis was performed using Rev man 5.3 software on survival-free BPD at grades 2 and 3 (SF-BPD), the incidence of BPD, mortality, duration of invasive ventilation, length of hospital stays, and complications in both groups.

Results

The review included 11 studies (three randomized controlled trials, one non-randomized controlled trial, and seven observational studies) with 785 participants. Data analysis showed that HFOV-VG could increase SF-BPD in preterm infants (OR 3.15, 95%CI 1.66–5.98) without reducing the overall incidence of BPD compared with HFOV alone. HFOV-VG may offer advantages in shortening the duration of MV and total hospital stay, potentially reducing mortality and the incidence of air leak syndrome.

Conclusions existing

Studies showed that HFOV-VG had certain advantages in improving oxygenation and stable ventilation to protect neonatal lungs. HFOV-VG could increase SF-BPD in preterm infants with GA < 32 weeks without reducing the overall incidence of BPD compared with HFOV alone.

Impact

Existing evidence suggested that HFOV-VG ventilation strategies could increase SF-BPD in preterm infants with GA < 32 weeks without reducing the overall incidence of BPD compared with HFOV alone.

HFOV-VG ventilation strategy has certain advantages in improving oxygenation and stable ventilation to protect neonatal lungs.

The effects of HFOV-VG vs. HFOV in neonates remain to be further validated by additional large sample, multicenter RCTs.