Shear-wave elastography in renal stiffness in children with hematuria and/or proteinuria

期刊论文
发表日期：

2024年7月3日

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Xingyu Chen,
Xinxin Huang,
Xiuyun Li,
Ping Chi,
Yinghua Lin,
Xiaoying Cui,
Maosheng Xu,
Liang Wang,
Chunpeng Zou

摘要

Background

We sought to evaluate renal stiffness in children with hematuria and/or proteinuria using shear wave elastography (SWE) and to investigate the clinical value of renal stiffness in children with hematuria and/or proteinuria.

Methods

According to the results of urinary occult blood and urinary protein tests, 349 pediatric patients were categorized into one of four groups: pure hematuria (HU), pure proteinuria (PU), concomitant hematuria and proteinuria (HUPU), or control (non-HUPU). Patient demographic data, laboratory test results, and renal ultrasound data were collected.

Results

There were significant differences in cortical/medullary elasticity among the four groups (the most sensitive cutoff value between HU and PU was 1.72) (P < 0.05). We found that hematuria and proteinuria interacted with renal cortical elasticity (P < 0.05) but that hematuria and proteinuria did not interact with renal medullary elasticity or cortical/medullary elasticity (P > 0.05). Renal elasticity values correlated with sex, age, body surface area, body mass index, qualitative urinary protein, urine N-acetyl-β-D-glucosaminidase, 24-hour urinary protein quantity, renal volume, and renal cortical thickness (P < 0.05).

Conclusions

SWE can be used to detect changes in renal stiffness in children with hematuria and/or proteinuria. SWE is beneficial for the early detection of glomerular disease in children with abnormal urine test results.

Impact

This study evaluated the utility of shear wave elastography for the assessment of renal elasticity in pediatric patients presenting with hematuria and/or proteinuria.

Children with pure proteinuria had significantly higher renal cortical/medullary elasticity values than those with pure hematuria.

An interaction effect between hematuria and proteinuria on renal cortical stiffness was observed.

Shear wave elastography can be used as a tool to assess early renal injury in children with urinalysis abnormalities.