Umbilical cord blood culture for early onset sepsis in preterm infants

Background

Umbilical cord blood culture (UCBC) may have a diagnostic utility for early onset sepsis (EOS) detection in preterm infants. It may prevent sampling the newborn and collect a higher volume of blood for pathogenic identification.

Methods

Retrospective analysis at a tertiary care center in Canada of preterm infants ≤ 34 0/7 weeks’ gestation with UCBC taken at birth.

Results

Of 505 admitted infants, 195 had UCBC. 170 UCBCs were negative; 44 of these had also negative neonatal blood culture (NBC). No infants with negative UCBC showed EOS symptoms in the first week of life. 25 UCBCs were positive: 18 were contaminants (all with negative NBC) and 7 were confirmed as EOS. 18 infants with UCBC contaminants remained asymptomatic. 7 EOS cases were identified, with varying bacteriological profiles; 5 displayed sepsis symptoms while 2 were asymptomatic. Risk of EOS increased with prolonged rupture of membranes.

Conclusions

UCBC effectively detected EOS establishing it as a method with possibly better diagnostic performance than NBC in high-risk neonates. Further studies are needed to improve UCBC technique and lower contamination rates.

Impact

Umbilical cord blood culture has a higher bacterial identification rate than peripheral venous blood culture for the early identification of early-onset sepsis in preterm infants.

Umbilical cord blood cultures that showed no growth were reliable predictors of not developing early onset sepsis.

Umbilical cord blood culture should be considered as part of the evaluation for early onset sepsis in the preterm infants.