Scholarlink

<p>Despite advancements in diagnostics and treatment, lung adenocarcinoma (LUAD) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Identifying novel molecular mechanisms that regulate the progression of LUAD is crucial for improving therapeutic outcomes. Our study reveals that CRTAC1, a natural tumor suppressor, can block the integrin pathway and inhibit the growth and metastasis of LUAD cells. Specifically, our study reveals that CRTAC1 is downregulated significantly in LUAD tissues and that its expression correlates positively with patient survival. Functionally, CRTAC1 inhibits the proliferation, migration, and invasion of LUAD cells both in vitro and in vivo by suppressing integrin/FAK signaling. These findings highlight CRTAC1 as a potential therapeutic target for LUAD, offering new avenues for treatment strategies aimed at reducing tumor progression.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

CRTAC1 inhibits progression of lung adenocarcinoma by suppressing integrin/FAK signaling

  • 期刊论文

  • 发表日期：

    2026年2月18日

查看全文
  • Yu Liu,
  • Yuanyuan Chang,
  • Haiying Li,
  • Junyu Wang,
  • Honglei Jin,
  • Chuanshu Huang,
  • Lingling Zhao,
  • Qipeng Xie,
  • Haishan Huang

摘要

Despite advancements in diagnostics and treatment, lung adenocarcinoma (LUAD) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Identifying novel molecular mechanisms that regulate the progression of LUAD is crucial for improving therapeutic outcomes. Our study reveals that CRTAC1, a natural tumor suppressor, can block the integrin pathway and inhibit the growth and metastasis of LUAD cells. Specifically, our study reveals that CRTAC1 is downregulated significantly in LUAD tissues and that its expression correlates positively with patient survival. Functionally, CRTAC1 inhibits the proliferation, migration, and invasion of LUAD cells both in vitro and in vivo by suppressing integrin/FAK signaling. These findings highlight CRTAC1 as a potential therapeutic target for LUAD, offering new avenues for treatment strategies aimed at reducing tumor progression.