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<p>Invariant natural killer T (iNKT) cells, previously considered to be tissue-resident, are an emerging and versatile allogeneic cell therapy with potent anti-tumor activity, acting at the interplay between innate and adaptive immune responses. We report an unprecedented complete remission in a heavily pre-treated metastatic germ cell neoplasm, using ex vivo expanded allogeneic iNKT cells, warranting further trials.</p>

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Salvage therapy with allogeneic invariant natural killer cells in a heavily pre-treated germ cell tumor

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月10日

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  • Benjamin Garmezy,
  • Joseph E. Grossman,
  • Jennifer Buell,
  • Thiago Favano,
  • Justin Stebbing,
  • Steven O’Day,
  • Marco A. Purbhoo,
  • Dhan Chand,
  • F. Anthony Greco

摘要

Invariant natural killer T (iNKT) cells, previously considered to be tissue-resident, are an emerging and versatile allogeneic cell therapy with potent anti-tumor activity, acting at the interplay between innate and adaptive immune responses. We report an unprecedented complete remission in a heavily pre-treated metastatic germ cell neoplasm, using ex vivo expanded allogeneic iNKT cells, warranting further trials.