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<p>Gastric cancer (GC) remains a lethal malignancy with limited therapeutic targets, while recent studies revealed YAP could be a promising target for GC treatment. In our study, we identify oxytocin receptor (OXTR) as an important regulator of Hippo/YAP axis. Through bioinformatics analysis, RNA sequencing analysis, functional research, and molecular mechanism research, we found that OXTR could facilitate Hippo/YAP axis, while YAP were shown to bind the OXTR promoter, enhancing its expression and establishing an interesting positive feedback loop. These findings propose the significance of OXTR in GC progression and its potential as a therapeutic target for YAP-driven cancer.</p><p></p>

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The interplay between oxytocin receptor and YAP in regulating gastric cancer progression

  • 期刊论文

  • 发表日期：

    2025年7月2日

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  • Ziping Liu,
  • Honghu Wang,
  • Chenmiao Zhang,
  • Hao Qi,
  • Zhongbo Li,
  • Yanan Sun,
  • Beibei Wang,
  • Fangyu Shen,
  • Zehao Hong,
  • Jian Zhu,
  • Xin Li,
  • Yinlu Ding,
  • Kai Li

摘要

Gastric cancer (GC) remains a lethal malignancy with limited therapeutic targets, while recent studies revealed YAP could be a promising target for GC treatment. In our study, we identify oxytocin receptor (OXTR) as an important regulator of Hippo/YAP axis. Through bioinformatics analysis, RNA sequencing analysis, functional research, and molecular mechanism research, we found that OXTR could facilitate Hippo/YAP axis, while YAP were shown to bind the OXTR promoter, enhancing its expression and establishing an interesting positive feedback loop. These findings propose the significance of OXTR in GC progression and its potential as a therapeutic target for YAP-driven cancer.