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Aim <p>To investigate the role of <i>ADIPOQ</i> gene in gestational diabetes mellitus (GDM).</p> Methods <p>We genotyped single nucleotide polymorphisms (SNPs) rs266729 and rs1501299 within the <i>ADIPOQ</i> gene in a cohort of 1157 pregnant women of north Chinese Han ethnicity. This cohort comprised 560 pregnant women diagnosed with GDM and 597 pregnant women who exhibited normal oral glucose tolerance test at 24–28 weeks’ gestation. All participants were recruited from the Department of Obstetrics and Gynecology at the Second Affiliated Hospital of Harbin Medical University. Additionally, we used conventional bioinformatics analysis methods to conduct multi-omics analysis (transcriptome, epigenome, and single-cell level) of <i>ADIPOQ-</i>regulated GDM.</p> Results <p>The systolic blood flow velocity/diastolic blood flow velocity (S/D) ratio of the umbilical artery in GDM patients with CC genotype of rs266729 and GG genotype of rs1501299 was higher than control. Single-cell analysis suggested that <i>ADIPOQ</i> was expressed in extravillous trophoblast (EVT), T cell, monocytes, myelocyte, NK cell and syncytiotrophoblast (SCT). Functional enrichment analysis showed <i>ADIPOQ</i> gene was associated with response to nutrient levels, fat cell differentiation.</p> Conclusion <p>The findings of our study indicate a correlation between SNPs of <i>ADIPOQ</i> in GDM patients, and <i>ADIPOQ</i> is involved in the transcriptional regulation of GDM.</p>

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Multi-omics integration analysis and association study reveal the potential of ADIPOQ function in gestational diabetes mellitus

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月1日

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  • Xiaoying Li,
  • Tianshuang Jia,
  • Yingnan Wu,
  • Yanqing Peng,
  • Yanan Feng,
  • Liping Gong,
  • Shuang Dong,
  • Jiawei Tian,
  • Litao Sun

摘要

Aim

To investigate the role of ADIPOQ gene in gestational diabetes mellitus (GDM).

Methods

We genotyped single nucleotide polymorphisms (SNPs) rs266729 and rs1501299 within the ADIPOQ gene in a cohort of 1157 pregnant women of north Chinese Han ethnicity. This cohort comprised 560 pregnant women diagnosed with GDM and 597 pregnant women who exhibited normal oral glucose tolerance test at 24–28 weeks’ gestation. All participants were recruited from the Department of Obstetrics and Gynecology at the Second Affiliated Hospital of Harbin Medical University. Additionally, we used conventional bioinformatics analysis methods to conduct multi-omics analysis (transcriptome, epigenome, and single-cell level) of ADIPOQ-regulated GDM.

Results

The systolic blood flow velocity/diastolic blood flow velocity (S/D) ratio of the umbilical artery in GDM patients with CC genotype of rs266729 and GG genotype of rs1501299 was higher than control. Single-cell analysis suggested that ADIPOQ was expressed in extravillous trophoblast (EVT), T cell, monocytes, myelocyte, NK cell and syncytiotrophoblast (SCT). Functional enrichment analysis showed ADIPOQ gene was associated with response to nutrient levels, fat cell differentiation.

Conclusion

The findings of our study indicate a correlation between SNPs of ADIPOQ in GDM patients, and ADIPOQ is involved in the transcriptional regulation of GDM.