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<p>Relapse to opioid use during abstinence is often triggered by drug-associated cues but the persistence of this effect during prolonged abstinence is unknown. Using a rat model, we found that relapse provoked by heroin-predictive discriminative stimuli persisted for over one year of abstinence, suggesting enduring, potentially lifelong opioid relapse vulnerability.</p>

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Persistent vulnerability to heroin relapse after more than one year of abstinence in rats

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Rajtarun Madangopal,
  • Olivia R. Drake,
  • Diana Q. Pham,
  • Veronica A. Lennon,
  • Sophia J. Weber,
  • Justine Lee,
  • Adekemi Sobukunola,
  • Ava R. Holmes,
  • Omodolapo Nurudeen,
  • Yavin Shaham,
  • Bruce T. Hope

摘要

Relapse to opioid use during abstinence is often triggered by drug-associated cues but the persistence of this effect during prolonged abstinence is unknown. Using a rat model, we found that relapse provoked by heroin-predictive discriminative stimuli persisted for over one year of abstinence, suggesting enduring, potentially lifelong opioid relapse vulnerability.