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<p>The present study determined the effectiveness of the glucagon-like peptide 1 agonist semaglutide to attenuate cocaine-vs-food choice in male and female rats. Repeated 5-day semaglutide treatment decreased cocaine choice and significantly reduced body weight. These preclinical results support the clinical evaluation of semaglutide as a candidate cocaine use disorder medication.</p>

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Repeated semaglutide treatment attenuates cocaine-vs-food choice in male and female rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月15日

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  • Nicholas Heslep,
  • Samuel A. Marsh,
  • Matthew L. Banks

摘要

The present study determined the effectiveness of the glucagon-like peptide 1 agonist semaglutide to attenuate cocaine-vs-food choice in male and female rats. Repeated 5-day semaglutide treatment decreased cocaine choice and significantly reduced body weight. These preclinical results support the clinical evaluation of semaglutide as a candidate cocaine use disorder medication.