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<p>As late-life depression is associated with a high degree of treatment resistance, understanding predictors of outcome may inform management. In this review, we examine a spectrum of factors that may moderate treatment response. These include clinical moderators related to depression presentation and history, social moderators, psychosocial stressors, personality, and cognitive factors. As there has been substantial research on biological predictors of response, we also include a review of neuroimaging moderators, including markers of accelerated brain aging, as well as other peripheral or central biomarkers of response.</p>

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Moderators of treatment response in late-life depression

  • 期刊论文

  • 发表日期：

    2026年2月10日

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  • David C. Steffens,
  • Breno S. Diniz,
  • Neha Jain,
  • Jessica Kluewer-D’Amico,
  • Kevin J. Manning,
  • Lihong Wang

摘要

As late-life depression is associated with a high degree of treatment resistance, understanding predictors of outcome may inform management. In this review, we examine a spectrum of factors that may moderate treatment response. These include clinical moderators related to depression presentation and history, social moderators, psychosocial stressors, personality, and cognitive factors. As there has been substantial research on biological predictors of response, we also include a review of neuroimaging moderators, including markers of accelerated brain aging, as well as other peripheral or central biomarkers of response.