Scholarlink

<p>Major Depressive Disorder (MDD) is a globally widespread mental health disorder that frequently remains underdiagnosed and inadequately treated. Recent advancements in circular RNAs (circRNAs) have illuminated their potential as biomarkers for a variety of diseases, including MDD. This review emphasizes the advantages of circRNA enrichment methodologies over traditional techniques, particularly isotachophoresis. Furthermore, the intricate role of circRNAs in the pathophysiological processes underlying MDD, as well as their integration with biosensor technology to improve diagnostic accuracy and efficiency, are synthesised. However, the clinical translation of circRNA-based diagnostics faces significant challenges, including the low abundance of circRNAs in bodily fluids, the need for highly sensitive and rapid detection platforms, and the lack of standardized, point-of-care compatible methods. A comprehensive overview of current circRNA detection methods, delineating their similarities and differences, is discussed. Insights for the anticipated advancements in quantitative and rapid circRNA detection is proposed. This review not only presents a thorough assessment of emerging trends in circRNA detection but also elaborates on primary techniques, traditional approaches, and recent innovations within the field of biosensor-based MDD diagnostics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Revolutionizing MDD diagnosis: the integrated role of circRNAs and biosensor technology

  • 期刊论文

  • 发表日期：

    2026年5月12日

查看全文
  • Wangang Zhu,
  • Yuchen Wang,
  • Chenghui Yu,
  • Nuno Pires,
  • Zhaochu Yang,
  • Haakon Karlsen,
  • Weixuan Jing,
  • Honghong Yao,
  • Bing Han,
  • Jinsong Ouyang,
  • Minjie Zhu,
  • Jose Higino Correia,
  • Danilo Demarchi,
  • Zhuangde Jiang,
  • Tao Dong

摘要

Major Depressive Disorder (MDD) is a globally widespread mental health disorder that frequently remains underdiagnosed and inadequately treated. Recent advancements in circular RNAs (circRNAs) have illuminated their potential as biomarkers for a variety of diseases, including MDD. This review emphasizes the advantages of circRNA enrichment methodologies over traditional techniques, particularly isotachophoresis. Furthermore, the intricate role of circRNAs in the pathophysiological processes underlying MDD, as well as their integration with biosensor technology to improve diagnostic accuracy and efficiency, are synthesised. However, the clinical translation of circRNA-based diagnostics faces significant challenges, including the low abundance of circRNAs in bodily fluids, the need for highly sensitive and rapid detection platforms, and the lack of standardized, point-of-care compatible methods. A comprehensive overview of current circRNA detection methods, delineating their similarities and differences, is discussed. Insights for the anticipated advancements in quantitative and rapid circRNA detection is proposed. This review not only presents a thorough assessment of emerging trends in circRNA detection but also elaborates on primary techniques, traditional approaches, and recent innovations within the field of biosensor-based MDD diagnostics.