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<p>The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of East Asian populations in brain research. By integrating genome, epigenome, transcriptome, proteome (including multiple post-translational modifications), and metabolome data, CBMAP is set to provide a rich and invaluable resource for investigating the molecular underpinnings of aging-related brain phenotypes and neuropsychiatric disorders. Leveraging high-throughput omics data and advanced technologies, such as spatial transcriptomics, proteomics, and single-nucleus 3D chromatin structure analysis, this atlas will serve as a crucial resource for the brain science community, illuminating disease mechanisms and enhancing the utility of data from genome-wide association studies (GWAS). CBMAP is also poised to accelerate drug discovery and precision medicine for brain disorders.</p>

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The China Brain Multi-omics Atlas Project (CBMAP)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月15日

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  • Dan Zhou,
  • Yuan Zhou,
  • Zeyu Sun,
  • Feiyang Ji,
  • Dandan Zhang,
  • Quan Wang,
  • Yijun Ruan,
  • Yongcheng Wang,
  • Yimin Zhu,
  • Xiaohui Sun,
  • Mulin Jun Li,
  • Changzheng Yuan,
  • Kefu Liu,
  • Lingyun Sun,
  • Wenli Zhai,
  • Jiayao Fan,
  • Keqing Zhu,
  • Wenying Qiu,
  • Xiaoxin Yan,
  • Chao Ma,
  • Yi Shen,
  • Aimin Bao,
  • Weihua Yue,
  • Yongyong Shi,
  • Chao Chen,
  • Jian Yang,
  • Shumin Duan,
  • Jing Zhang

摘要

The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of East Asian populations in brain research. By integrating genome, epigenome, transcriptome, proteome (including multiple post-translational modifications), and metabolome data, CBMAP is set to provide a rich and invaluable resource for investigating the molecular underpinnings of aging-related brain phenotypes and neuropsychiatric disorders. Leveraging high-throughput omics data and advanced technologies, such as spatial transcriptomics, proteomics, and single-nucleus 3D chromatin structure analysis, this atlas will serve as a crucial resource for the brain science community, illuminating disease mechanisms and enhancing the utility of data from genome-wide association studies (GWAS). CBMAP is also poised to accelerate drug discovery and precision medicine for brain disorders.