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<p>The relationship between adiposity and dopamine type-2 receptor binding potential (D2BP) in the human brain has been repeatedly studied for &gt;20 years with highly discrepant results, likely due to variable methodologies and differing study populations. We conducted a controlled inpatient feeding study to measure D2BP in the striatum using positron emission tomography with both [<sup>18</sup>F]fallypride and [<sup>11</sup>C]raclopride in pseudo-random order in 54 young adults with a wide range of body mass index (BMI 20–44 kg/m<sup>2</sup>). Within-subject D2BP measurements using the two tracers were moderately correlated (r = 0.47, <i>p</i> &lt; 0.001). D2BP was negatively correlated with BMI as measured by [<sup>11</sup>C]raclopride (r = −0.51; <i>p</i> &lt; 0.0001) but not [<sup>18</sup>F]fallypride (r = −0.01; <i>p</i> = 0.92) and these correlation coefficients were significantly different from each other (<i>p</i> &lt; 0.001). Given that [<sup>18</sup>F]fallypride has greater binding affinity to dopamine type-2 receptors than [<sup>11</sup>C]raclopride, which is more easily displaced by endogenous dopamine, our results suggest that adiposity is positively associated with increased striatal dopamine tone.ClinicalTrials.gov Identifier: NCT03648892</p>

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Striatal dopamine tone is positively associated with adiposity in humans as determined by PET using dual dopamine type-2 receptor antagonist tracers

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月6日

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  • Valerie L. Darcey,
  • Juen Guo,
  • Meible Chi,
  • Stephanie T. Chung,
  • Amber B. Courville,
  • Isabelle Gallagher,
  • Peter Herscovitch,
  • Rebecca Howard,
  • Melissa La Noire,
  • Lauren Milley,
  • Alex Schick,
  • Michael Stagliano,
  • Sara Turner,
  • Nicholas Urbanski,
  • Shanna Yang,
  • Eunha Yim,
  • Nan Zhai,
  • Megan S. Zhou,
  • Kevin D. Hall

摘要

The relationship between adiposity and dopamine type-2 receptor binding potential (D2BP) in the human brain has been repeatedly studied for >20 years with highly discrepant results, likely due to variable methodologies and differing study populations. We conducted a controlled inpatient feeding study to measure D2BP in the striatum using positron emission tomography with both [18F]fallypride and [11C]raclopride in pseudo-random order in 54 young adults with a wide range of body mass index (BMI 20–44 kg/m2). Within-subject D2BP measurements using the two tracers were moderately correlated (r = 0.47, p < 0.001). D2BP was negatively correlated with BMI as measured by [11C]raclopride (r = −0.51; p < 0.0001) but not [18F]fallypride (r = −0.01; p = 0.92) and these correlation coefficients were significantly different from each other (p < 0.001). Given that [18F]fallypride has greater binding affinity to dopamine type-2 receptors than [11C]raclopride, which is more easily displaced by endogenous dopamine, our results suggest that adiposity is positively associated with increased striatal dopamine tone.ClinicalTrials.gov Identifier: NCT03648892