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Objective <p>To evaluate whether an ultrasound-guided lung recruitment manoeuvre (LRM) can identify a positive end-expiratory pressure (PEEP) associated with improved aeration compared with clinically set PEEP during non-invasive respiratory support.</p> Study design <p>Feasibility study of 11 spontaneously breathing infants on continuous positive airway pressure or non-invasive ventilation. PEEP was increased stepwise by 2 cmH<sub>2</sub>O from 4 to 10 cmH<sub>2</sub>O. The PEEP with the lowest lung ultrasound score was recorded along with vital parameters.</p> Results <p>In 10 of 11 infants (91%; 95% confidence interval 62–99, <i>p</i> = 0.01), the LRM identified a PEEP with a lower lung ultrasound score than the clinically set level; five infants required a higher and five a lower PEEP. Clinical parameters were stable or improved.</p> Conclusion <p>In this pilot cohort, lung ultrasound-guided PEEP adjustment appeared feasible and was associated with favourable short-term changes in lung aeration. Larger studies are required to validate these preliminary findings and determine clinical utility.</p>

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Feasibility of lung ultrasound-guided positive end-expiratory pressure adjustment in newborns

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月28日

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  • Anna Holst Møller,
  • Christian Heiring,
  • Sebastian Pornpakdee Feldskou,
  • Katrin Klebermass-Schrehof,
  • Mette Høj Lauridsen,
  • Kasper Jacobsen Kyng

摘要

Objective

To evaluate whether an ultrasound-guided lung recruitment manoeuvre (LRM) can identify a positive end-expiratory pressure (PEEP) associated with improved aeration compared with clinically set PEEP during non-invasive respiratory support.

Study design

Feasibility study of 11 spontaneously breathing infants on continuous positive airway pressure or non-invasive ventilation. PEEP was increased stepwise by 2 cmH2O from 4 to 10 cmH2O. The PEEP with the lowest lung ultrasound score was recorded along with vital parameters.

Results

In 10 of 11 infants (91%; 95% confidence interval 62–99, p = 0.01), the LRM identified a PEEP with a lower lung ultrasound score than the clinically set level; five infants required a higher and five a lower PEEP. Clinical parameters were stable or improved.

Conclusion

In this pilot cohort, lung ultrasound-guided PEEP adjustment appeared feasible and was associated with favourable short-term changes in lung aeration. Larger studies are required to validate these preliminary findings and determine clinical utility.