Scholarlink

Objectives <p>To describe the impact of transcatheter PDA closure on renal function in these premature infants with and without pre-existing renal insufficiency.</p> Study design <p>This retrospective study was conducted by 4 U.S. pediatric centers and included 245 eligible patients who underwent successful transcatheter PDA device closure. Renal insufficiency in these patients was noted along with risk factors. Renal function over multiple time periods was assessed out to 2 months post intervention.</p> Results <p>In total, 245 eligible patients underwent successful transcatheter PDA device closure. In the first 24 h post device closure, the urine output increased from 3.7  to 4.1 ml/kg/h (<i>p</i> &lt; 0.001) with a decrease in serum creatinine (0.40  to 0.37 mg/dL, <i>p</i> &lt; 0.001) and blood urea nitrogen (16  to 12 mg/dL, <i>p</i> &lt; 0.001). This trend of improved renal function continued through 2 months post-device closure. A total of 59 patients (32%) met the definition for acute renal insufficiency prior to cardiac catheterization. The serum creatinine and BUN had a significantly greater decline from baseline for the AKI cohort in comparison to all others at both 1 week post procedure (–0.21 ± 0.04 vs –0.04 ± 0.03, <i>P</i> &lt; 0.0001 and –8.4 ± 1.8 vs –2.4 ± 1.4, <i>P</i> &lt; 0.001) and 1 month post procedure (–0.39 ± 0.04 vs –0.07 ± 0.03, <i>P</i> &lt; 0.0001 and –12.0 ± 1.8 vs –2.3 ± 1.5, <i>P</i> &lt; 0.0001).</p> Conclusion <p>All patients showed a positive trend in renal function post PDA device closure with a significant increase in urine output in the first 24 h post closure. Patients with acute renal insufficiency experienced notable improvement in renal function post PDA device closure, even with the use of contrast.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of transcatheter PDA closure on renal function in extremely low birth weight infants—a multicenter study

  • 期刊论文

  • 发表日期：

    2026年7月14日

查看全文
  • Christopher Herron,
  • Neha Ahluwalia,
  • Thomas Fagan,
  • Daisuke Kobayashi,
  • David Balzer,
  • Matthew Schwartz,
  • Tin Phan,
  • JangDong Seo,
  • Holly Newkirk,
  • Shabana Shahanavaz

摘要

Objectives

To describe the impact of transcatheter PDA closure on renal function in these premature infants with and without pre-existing renal insufficiency.

Study design

This retrospective study was conducted by 4 U.S. pediatric centers and included 245 eligible patients who underwent successful transcatheter PDA device closure. Renal insufficiency in these patients was noted along with risk factors. Renal function over multiple time periods was assessed out to 2 months post intervention.

Results

In total, 245 eligible patients underwent successful transcatheter PDA device closure. In the first 24 h post device closure, the urine output increased from 3.7  to 4.1 ml/kg/h (p < 0.001) with a decrease in serum creatinine (0.40  to 0.37 mg/dL, p < 0.001) and blood urea nitrogen (16  to 12 mg/dL, p < 0.001). This trend of improved renal function continued through 2 months post-device closure. A total of 59 patients (32%) met the definition for acute renal insufficiency prior to cardiac catheterization. The serum creatinine and BUN had a significantly greater decline from baseline for the AKI cohort in comparison to all others at both 1 week post procedure (–0.21 ± 0.04 vs –0.04 ± 0.03, P < 0.0001 and –8.4 ± 1.8 vs –2.4 ± 1.4, P < 0.001) and 1 month post procedure (–0.39 ± 0.04 vs –0.07 ± 0.03, P < 0.0001 and –12.0 ± 1.8 vs –2.3 ± 1.5, P < 0.0001).

Conclusion

All patients showed a positive trend in renal function post PDA device closure with a significant increase in urine output in the first 24 h post closure. Patients with acute renal insufficiency experienced notable improvement in renal function post PDA device closure, even with the use of contrast.