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Objective <p>Prophylactic vitamin K (pVitK) is recommended for all newborns to prevent vitamin K deficiency bleeding (VKDB), but reports of parental refusal are increasing. This study describes the possible drivers of no documented pVitK in a large US hospital network.</p> Study design <p>This retrospective cohort study consisted of full-term newborns born between 2017 and 2022, admitted to HCA Healthcare network facilities.</p> Results <p>884,876 newborns across 116 hospitals were included. 19,384 had no documented pVitK (2.2%). Using a multivariable model, having no documented pVitK was significantly associated with suspected VKDB bleeding (<i>p</i> = 0.018). Gestational age, maternal parity, maternal race, maternal ethnicity, and insurance type were the greatest predictors of lack of documented pVitK.</p> Conclusion <p>A lack of documented pVitK was associated with gestational age, maternal race and ethnicity, and an increased risk of suspected VKDB. This study identified areas for improved documentation and parental education.</p>

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Lack of documented prophylactic vitamin K administration in newborns: incidence, predictors, and bleeding outcomes in a large healthcare network population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Barry T. Bloom,
  • Mary Alice Keller,
  • Kaashif A. Ahmad,
  • Laura L. Daniel,
  • Anthony C. Rudine,
  • Mitchell E. Stern,
  • Gabrielle Blade,
  • Casey Martin,
  • Meredith Mattlin,
  • Xiaotong Fu,
  • JaMario J. Ayers,
  • Shanna A. Arnold Egloff

摘要

Objective

Prophylactic vitamin K (pVitK) is recommended for all newborns to prevent vitamin K deficiency bleeding (VKDB), but reports of parental refusal are increasing. This study describes the possible drivers of no documented pVitK in a large US hospital network.

Study design

This retrospective cohort study consisted of full-term newborns born between 2017 and 2022, admitted to HCA Healthcare network facilities.

Results

884,876 newborns across 116 hospitals were included. 19,384 had no documented pVitK (2.2%). Using a multivariable model, having no documented pVitK was significantly associated with suspected VKDB bleeding (p = 0.018). Gestational age, maternal parity, maternal race, maternal ethnicity, and insurance type were the greatest predictors of lack of documented pVitK.

Conclusion

A lack of documented pVitK was associated with gestational age, maternal race and ethnicity, and an increased risk of suspected VKDB. This study identified areas for improved documentation and parental education.