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Objective <p>Platelet transfusion thresholds for very low birth weight (VLBW, &lt;1500 g) infants vary widely, and the role of bleeding on platelet transfusion thresholds is uncertain.</p> Study design <p>This observational birth cohort study of VLBW infants born in 7 hospitals across the US examined pre-transfusion platelet counts in infants with and without bleeding who received at least 1 platelet transfusion in the first 3 weeks of life using mixed effect linear regression models.</p> Results <p>Of the 210 transfused infants, most (76%) had bleeding; intraventricular hemorrhage (IVH) was the most common (61%) bleeding type. Pre-transfusion platelet counts were not different among infants with or without bleeding diagnoses (56.3 vs 58.5 × 10<sup>3</sup>/µL, respectively; <i>P</i> = 0.7). However, infants with severe IVH had higher platelet counts (68.9 × 10<sup>3</sup>/µL) compared to the entire cohort (53.5 × 10<sup>3</sup>/µL, <i>P</i> = 0.01).</p> Conclusion <p>Infants with or without bleeding diagnoses had similar pre-transfusion platelet counts; infants with severe IVH had higher pre-transfusion platelet counts.</p>

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Pre-transfusion platelet counts and bleeding in very low birth weight infants

  • 期刊论文

  • 发表日期：

    2026年7月27日

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  • Elizabeth F. Stone,
  • Rebecca Birch,
  • Jeanne E. Hendrickson,
  • Erika M. Edwards,
  • Ruchika Goel,
  • Eldad A. Hod,
  • Matthew Karafin,
  • Oliver Karam,
  • Naomi L. C. Luban,
  • Jennifer McIntosh,
  • Gisela Marrero-Rivera,
  • Marianne E. Nellis,
  • Jeffrey VanWormer,
  • Nalan Yurtsever,
  • Cassandra D. Josephson,
  • Martha Sola-Visner,
  • Ravi M. Patel,
  • A. E. Mast,
  • L. Baumann Kreuziger,
  • E. A. Hod,
  • B. S. Custer,
  • J. E. Hendrickson,
  • B. R. Spencer,
  • K. Chapman,
  • E. Rowley,
  • N. L. Luban,
  • P. J. Norris,
  • M. Stone,
  • P. M. Ness,
  • C. D. Josephson,
  • S. H. Kleinman,
  • R. Tamburro,
  • B. Hailu,
  • D. Frank,
  • K. Malkin

摘要

Objective

Platelet transfusion thresholds for very low birth weight (VLBW, <1500 g) infants vary widely, and the role of bleeding on platelet transfusion thresholds is uncertain.

Study design

This observational birth cohort study of VLBW infants born in 7 hospitals across the US examined pre-transfusion platelet counts in infants with and without bleeding who received at least 1 platelet transfusion in the first 3 weeks of life using mixed effect linear regression models.

Results

Of the 210 transfused infants, most (76%) had bleeding; intraventricular hemorrhage (IVH) was the most common (61%) bleeding type. Pre-transfusion platelet counts were not different among infants with or without bleeding diagnoses (56.3 vs 58.5 × 103/µL, respectively; P = 0.7). However, infants with severe IVH had higher platelet counts (68.9 × 103/µL) compared to the entire cohort (53.5 × 103/µL, P = 0.01).

Conclusion

Infants with or without bleeding diagnoses had similar pre-transfusion platelet counts; infants with severe IVH had higher pre-transfusion platelet counts.