Scholarlink

Objective <p>To determine the incidence, risk factors, and outcomes associated with subcutaneous fat necrosis (SCFN) in a regional cohort of newborns treated with therapeutic hypothermia (TH) for neonatal encephalopathy (NE).</p> Study design <p>Data from a regional Neonatal Encephalopathy Registry was retrospectively analysed. All newborns treated with TH between 2018 and 2022 were included. The primary outcome was the incidence of SCFN. Secondary outcomes included associated risk factors and complications.</p> Results <p>SCFN occurred in 4% of newborns (20/499) undergoing TH. Factors associated with SCFN included elevated maternal BMI, maternal preeclampsia/hypertension, pyrexia during labor, earlier initiation of active cooling, thrombocytopenia, and blood product administration. Half of the SCFN cases developed hypercalcemia. SCFN was associated with longer hospital stay (median 11.5 vs. 8 days, <i>p</i> = 0.007).</p> Conclusion <p>In this large, contemporary cohort, SCFN occurred in 4% of newborns with NE treated with TH. Enhanced monitoring and risk stratification may facilitate early diagnosis and improve management outcomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Incidence and risk factor profile for subcutaneous fat necrosis among newborns undergoing therapeutic hypothermia: a multi-center regional cohort

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月6日

查看全文
  • Brian H. Walsh,
  • Hoda El-Shibiny,
  • Sara Cherkerzian,
  • Sara V. Bates,
  • Munish Gupta,
  • Anne Hansen,
  • Emily Herzberg,
  • Janet S. Soul,
  • Terrie Inder,
  • Mohamed El-Dib

摘要

Objective

To determine the incidence, risk factors, and outcomes associated with subcutaneous fat necrosis (SCFN) in a regional cohort of newborns treated with therapeutic hypothermia (TH) for neonatal encephalopathy (NE).

Study design

Data from a regional Neonatal Encephalopathy Registry was retrospectively analysed. All newborns treated with TH between 2018 and 2022 were included. The primary outcome was the incidence of SCFN. Secondary outcomes included associated risk factors and complications.

Results

SCFN occurred in 4% of newborns (20/499) undergoing TH. Factors associated with SCFN included elevated maternal BMI, maternal preeclampsia/hypertension, pyrexia during labor, earlier initiation of active cooling, thrombocytopenia, and blood product administration. Half of the SCFN cases developed hypercalcemia. SCFN was associated with longer hospital stay (median 11.5 vs. 8 days, p = 0.007).

Conclusion

In this large, contemporary cohort, SCFN occurred in 4% of newborns with NE treated with TH. Enhanced monitoring and risk stratification may facilitate early diagnosis and improve management outcomes.