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Objective <p>Investigate the association between vitamin D status (as measured by 25-hydroxyvitamin D concentration [25(OH)D]) and gestational age at delivery.</p> Study design <p>This was a retrospective chart review of electronic medical records (<i>n</i> = 15,506) from women delivering at the Medical University of South Carolina, with first maternal 25(OH)D concentrations measured from January 2016 to March 2024.</p> Result <p>Women delivering &lt;37 weeks (<i>n</i> = 1652; 31.3 ± 17.8 ng/mL) had lower 25(OH)D concentrations compared to those delivering at 37 weeks or later (<i>n</i> = 13,451; 34.8 ± 17.3 ng/mL), with a mean difference of –3.46 ng/mL (95% Confidence Interval (CI): –4.54 to –2.38, <i>p</i> &lt; 0.0001). This difference was even more pronounced among women delivering before 32 weeks (<i>n</i> = 385; 26.2 ± 14.9 ng/mL), who had substantially lower 25(OH)D concentrations than term deliveries, with a mean difference of –8.56 ng/mL (95% CI: –10.70 to –6.42, <i>p</i> &lt; 0.0001).</p> Conclusion <p>Maternal vitamin D status was associated with gestational age at delivery. Lower maternal 25(OH)D concentrations were observed among women who delivered preterm compared with those delivering at term. These findings suggest a potential relationship between vitamin D status and preterm birth and support further research into whether optimizing vitamin D status during pregnancy may improve perinatal outcomes.</p>

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Maternal vitamin D status and preterm birth: an eight-year retrospective cohort study in the Southeastern United States

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  • 发表日期：

    2026年6月22日

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  • Anjali G. Borsum,
  • Maya F. Andrade,
  • Myla D. Ebeling,
  • Jeffrey E. Korte,
  • Donna D. Johnson,
  • Roger B. Newman,
  • Bruce W. Hollis,
  • Carol L. Wagner

摘要

Objective

Investigate the association between vitamin D status (as measured by 25-hydroxyvitamin D concentration [25(OH)D]) and gestational age at delivery.

Study design

This was a retrospective chart review of electronic medical records (n = 15,506) from women delivering at the Medical University of South Carolina, with first maternal 25(OH)D concentrations measured from January 2016 to March 2024.

Result

Women delivering <37 weeks (n = 1652; 31.3 ± 17.8 ng/mL) had lower 25(OH)D concentrations compared to those delivering at 37 weeks or later (n = 13,451; 34.8 ± 17.3 ng/mL), with a mean difference of –3.46 ng/mL (95% Confidence Interval (CI): –4.54 to –2.38, p < 0.0001). This difference was even more pronounced among women delivering before 32 weeks (n = 385; 26.2 ± 14.9 ng/mL), who had substantially lower 25(OH)D concentrations than term deliveries, with a mean difference of –8.56 ng/mL (95% CI: –10.70 to –6.42, p < 0.0001).

Conclusion

Maternal vitamin D status was associated with gestational age at delivery. Lower maternal 25(OH)D concentrations were observed among women who delivered preterm compared with those delivering at term. These findings suggest a potential relationship between vitamin D status and preterm birth and support further research into whether optimizing vitamin D status during pregnancy may improve perinatal outcomes.