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Objective <p>Neonatal sepsis remains a leading cause of neonatal mortality, yet comprehensive evaluations of its current and future burden are limited. This study assessed global, regional, and national trends and projected mortality through 2050.</p> Study design <p>Data from the UN child mortality database (2000–2021) across 194 countries were analyzed. Neonatal sepsis was defined using ICD-10 codes P35–P39, excluding P37.3–P37.4. Trends were assessed using annual percentage change, and mortality was projected under three scenarios: continuation of current trends, convergence to high-income country trends, and attainment of the greatest observed national reduction.</p> Results <p>In 2021, the global neonatal sepsis mortality rate was 129.34 per 100,000 live births, a 41.6% reduction since 2000. West and Central Africa had the highest mortality and slowest decline. By 2050, mortality is projected to decline to 61.49 per 100,000.</p> Conclusions <p>Despite progress, substantial regional disparities persist, highlighting the need for targeted interventions in high-burden regions.</p>

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Temporal trends and patterns in neonatal sepsis mortality across 194 countries, 2000–2021, with projections up to 2050

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Soeun Kim,
  • Kyeongmin Lee,
  • Tae Hyeon Kim,
  • Jaehyeong Cho,
  • Jiyeon Oh,
  • Sooji Lee,
  • Seohyun Hong,
  • Dongjin Yeo,
  • Lee Smith,
  • André Hajek,
  • Yerin Hwang,
  • Selin Woo,
  • Hyeon Seok Hwang,
  • Dong Keon Yon

摘要

Objective

Neonatal sepsis remains a leading cause of neonatal mortality, yet comprehensive evaluations of its current and future burden are limited. This study assessed global, regional, and national trends and projected mortality through 2050.

Study design

Data from the UN child mortality database (2000–2021) across 194 countries were analyzed. Neonatal sepsis was defined using ICD-10 codes P35–P39, excluding P37.3–P37.4. Trends were assessed using annual percentage change, and mortality was projected under three scenarios: continuation of current trends, convergence to high-income country trends, and attainment of the greatest observed national reduction.

Results

In 2021, the global neonatal sepsis mortality rate was 129.34 per 100,000 live births, a 41.6% reduction since 2000. West and Central Africa had the highest mortality and slowest decline. By 2050, mortality is projected to decline to 61.49 per 100,000.

Conclusions

Despite progress, substantial regional disparities persist, highlighting the need for targeted interventions in high-burden regions.