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Objective <p>Using a quality improvement (QI) framework, we aimed to reduce the number of transfusions of packed red blood cells (pRBC) through adoption of evidence based more restrictive transfusion thresholds.</p> Methods <p>A SMART aim was developed to decrease pRBC transfusions in infants less than 35 weeks gestation at birth by approximately 25 percent from the baseline rate of 28/1000 patient days by 12/31/2024 through implementation of a transfusion protocol with more restrictive thresholds. Five sequential Plan-Do-Study-Act cycles incorporated guidelines to decrease transfusions. Statistical Process Control charts (QI Macros SPC Software for Microsoft Excel) were used to track time-ordered data.</p> Results <p>pRBC transfusions decreased from 28/1000 patient days to 18.3/1000 patient days below the target of 21/1000 patient days over a 16-month period.</p> Conclusion <p>A transition to more restrictive transfusion thresholds was done successfully in our unit with a robust framework leading to fewer pRBC transfusions.</p>

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Decreasing packed red blood cell (pRBC) transfusions in neonates through quality improvement

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月23日

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  • Valerie Elberson,
  • Kavya Rao,
  • Sheetal Chepuri,
  • Praveen Chandrasekharan

摘要

Objective

Using a quality improvement (QI) framework, we aimed to reduce the number of transfusions of packed red blood cells (pRBC) through adoption of evidence based more restrictive transfusion thresholds.

Methods

A SMART aim was developed to decrease pRBC transfusions in infants less than 35 weeks gestation at birth by approximately 25 percent from the baseline rate of 28/1000 patient days by 12/31/2024 through implementation of a transfusion protocol with more restrictive thresholds. Five sequential Plan-Do-Study-Act cycles incorporated guidelines to decrease transfusions. Statistical Process Control charts (QI Macros SPC Software for Microsoft Excel) were used to track time-ordered data.

Results

pRBC transfusions decreased from 28/1000 patient days to 18.3/1000 patient days below the target of 21/1000 patient days over a 16-month period.

Conclusion

A transition to more restrictive transfusion thresholds was done successfully in our unit with a robust framework leading to fewer pRBC transfusions.