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Objective <p>To determine adherence and safety of a diagnostic (culture, urinalysis) and therapeutic (5-day antibiotic course with a time-out) guideline for urinary tract infection (UTI) in the Neonatal Intensive Care Unit</p> Study design <p>Prospective surveillance of non-bacteremic UTIs from 11/2020-12/2022. Safety outcomes were defined by re-initiation of antibiotics within 7 days for a subsequent UTI due to the same organism and overall and UTI-related mortality.</p> Results <p>77 infants received treatment for 93 UTIs with 77% (72/93) adherence to diagnostic criteria; 90% (82/91) of infants received ≤6 days of definitive treatment (median [IQR] antibiotic duration 5 [5–6] days). Antibiotics were restarted within 7 days for a recurrent (same organism) UTI in 1/91 (1%) UTIs. Mortality was 4% (4/93); none were due to UTI.</p> Conclusion <p>Adherence to diagnostic UTI criteria was 77%. 90% of infants received short course treatment that was associated with a 1% failure rate. No safety concern was identified.</p>

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Urinary tract infection in the neonatal intensive care unit

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月29日

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  • Jacqueline Magers,
  • Alexandra Burton,
  • Pavel Prusakov,
  • Natalie O. White,
  • Randy R. Miller,
  • Richard Moraille,
  • Anthony R. Theile,
  • Pablo J. Sánchez,
  • Pablo J. Sánchez,
  • Jacqueline K. Magers,
  • Joshua R. Watson,
  • Jeanette Taveras,
  • Melinda Albertson,
  • Wai-Yin Mandy Tam,
  • Tommy Nathaniel Johnson-Roddenberry,
  • Maria Jebbia,
  • Maclain J. Magee,
  • Roopali Bapat

摘要

Objective

To determine adherence and safety of a diagnostic (culture, urinalysis) and therapeutic (5-day antibiotic course with a time-out) guideline for urinary tract infection (UTI) in the Neonatal Intensive Care Unit

Study design

Prospective surveillance of non-bacteremic UTIs from 11/2020-12/2022. Safety outcomes were defined by re-initiation of antibiotics within 7 days for a subsequent UTI due to the same organism and overall and UTI-related mortality.

Results

77 infants received treatment for 93 UTIs with 77% (72/93) adherence to diagnostic criteria; 90% (82/91) of infants received ≤6 days of definitive treatment (median [IQR] antibiotic duration 5 [5–6] days). Antibiotics were restarted within 7 days for a recurrent (same organism) UTI in 1/91 (1%) UTIs. Mortality was 4% (4/93); none were due to UTI.

Conclusion

Adherence to diagnostic UTI criteria was 77%. 90% of infants received short course treatment that was associated with a 1% failure rate. No safety concern was identified.