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Objective <p>This study evaluated clinical, laboratory, and ultrasonographic factors associated with UTI in neonates hospitalized for unexplained hyperbilirubinemia.</p> Study design <p>This retrospective cohort study included 96 neonates hospitalized for unexplained hyperbilirubinemia requiring phototherapy. UTI was defined by pyuria (&gt;5 WBC/high-power field) and growth of a single uropathogen (≥50,000 CFU/mL) from catheterized urine samples. Neonates were classified as UTI-positive (<i>n</i> = 30) or UTI-negative (<i>n</i> = 66). Demographic characteristics, bilirubin levels, inflammatory markers, and renal ultrasonography findings were compared.</p> Results <p>UTI was diagnosed in 31.2% of neonates. Bilirubin levels, white blood cell counts, and C- reactive protein concentrations did not differ between groups. Pathological renal ultrasonography findings were significantly more frequent in the UTI group and were independently associated with UTI (odds ratio 4.62; 95% CI 1.39–15.40).</p> Conclusion <p>Renal ultrasonography findings are strongly associated with UTI in hospitalized neonates with unexplained hyperbilirubinemia and may serve as a useful adjunctive evaluation tool in this high-risk population.</p>

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Renal ultrasonography findings are associated with urinary tract infection in neonates with asymptomatic hyperbilirubinemia

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Emine Ergül Sarı,
  • Özgül Salihoğlu

摘要

Objective

This study evaluated clinical, laboratory, and ultrasonographic factors associated with UTI in neonates hospitalized for unexplained hyperbilirubinemia.

Study design

This retrospective cohort study included 96 neonates hospitalized for unexplained hyperbilirubinemia requiring phototherapy. UTI was defined by pyuria (>5 WBC/high-power field) and growth of a single uropathogen (≥50,000 CFU/mL) from catheterized urine samples. Neonates were classified as UTI-positive (n = 30) or UTI-negative (n = 66). Demographic characteristics, bilirubin levels, inflammatory markers, and renal ultrasonography findings were compared.

Results

UTI was diagnosed in 31.2% of neonates. Bilirubin levels, white blood cell counts, and C- reactive protein concentrations did not differ between groups. Pathological renal ultrasonography findings were significantly more frequent in the UTI group and were independently associated with UTI (odds ratio 4.62; 95% CI 1.39–15.40).

Conclusion

Renal ultrasonography findings are strongly associated with UTI in hospitalized neonates with unexplained hyperbilirubinemia and may serve as a useful adjunctive evaluation tool in this high-risk population.