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Objective <p>To compare outcomes in young adults born prematurely with and without symptomatic patent ductus arteriosus (PDA) during infancy.</p> Study design <p>Young adults born preterm (≤32 weeks gestation; <i>n</i> = 107) were recruited from the Parkland Health Neonatal Intensive Care Unit (NICU) Registry and compared based on presence of symptomatic PDA during their NICU stay (<i>n</i> = 23 with PDA), defined as clinical evidence of large left-to-right shunt or congestive heart failure.</p> Results <p>Systolic blood pressure was similar, but the PDA group exhibited higher resting diastolic blood pressure (80 ± 10 versus 74 ± 12 mmHg, <i>p</i> = 0.02). Biventricular systolic function was similar. However, tissue Doppler imaging (TDI) velocities at the lateral/septal aspect of the mitral annulus were lower and RV end-diastolic diameter larger in the PDA group.</p> Conclusions <p>Individuals born preterm with a symptomatic PDA exhibited elevated diastolic blood pressure, slightly lower diastolic function, and larger right ventricular size in early adulthood.</p>

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Long-term outcomes in adults born preterm with symptomatic patent ductus arteriosus

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月15日

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  • Alysha Joseph,
  • Alvin Chandra,
  • Gregory P. Barton,
  • Nataly J. Sanchez-Solano,
  • Jarett D. Berry,
  • Kara N. Goss

摘要

Objective

To compare outcomes in young adults born prematurely with and without symptomatic patent ductus arteriosus (PDA) during infancy.

Study design

Young adults born preterm (≤32 weeks gestation; n = 107) were recruited from the Parkland Health Neonatal Intensive Care Unit (NICU) Registry and compared based on presence of symptomatic PDA during their NICU stay (n = 23 with PDA), defined as clinical evidence of large left-to-right shunt or congestive heart failure.

Results

Systolic blood pressure was similar, but the PDA group exhibited higher resting diastolic blood pressure (80 ± 10 versus 74 ± 12 mmHg, p = 0.02). Biventricular systolic function was similar. However, tissue Doppler imaging (TDI) velocities at the lateral/septal aspect of the mitral annulus were lower and RV end-diastolic diameter larger in the PDA group.

Conclusions

Individuals born preterm with a symptomatic PDA exhibited elevated diastolic blood pressure, slightly lower diastolic function, and larger right ventricular size in early adulthood.