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Objective <p>Characterize variation of macronutrient and bioactive composition between levels of human milk-derived human milk fortifier (HM-HMF), and between donor human milk (DHM) from commercial vs non-profit banks.</p> Study design <p>Macronutrients, Immunoglobulin A (IgA), and cortisol levels were measured in 10 lots of each HM-HMF product (20, 24, 26, 28, and 30 (<i>n</i> = 5) kcal/oz), including both “ready to feed” products and fortifiers reconstituted in donor milk.</p> Results <p>Caloric density, protein, fat, carbohydrate, and total IgA concentration generally increased with the level of HM-HMF labeled caloric density, while cortisol concentration did not. Protein concentration of DHM did not differ between commercial and non-profit milk banks. Carbohydrates, fat, calories, and cortisol were higher, and IgA was lower in DHM from a commercial milk bank. Lot-to-lot variability of all components, besides cortisol, was lower in commercial DHM.</p> Conclusion <p>Macronutrient composition and variability differ in DHM from commercial vs non-profit milk banks.</p>

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Macronutrient and bioactive profiles of donor milk differ in commercial vs non-profit milk banks

  • 期刊论文

  • 发表日期：

    2026年4月21日

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  • Tanner Tarkleson,
  • Danielle Ackley,
  • Laura Cole,
  • Manisha Srivastava,
  • Lori Scholer,
  • Carrie Gale,
  • Jeffrey Meyers,
  • Carl D’ Angio,
  • Bridget Young

摘要

Objective

Characterize variation of macronutrient and bioactive composition between levels of human milk-derived human milk fortifier (HM-HMF), and between donor human milk (DHM) from commercial vs non-profit banks.

Study design

Macronutrients, Immunoglobulin A (IgA), and cortisol levels were measured in 10 lots of each HM-HMF product (20, 24, 26, 28, and 30 (n = 5) kcal/oz), including both “ready to feed” products and fortifiers reconstituted in donor milk.

Results

Caloric density, protein, fat, carbohydrate, and total IgA concentration generally increased with the level of HM-HMF labeled caloric density, while cortisol concentration did not. Protein concentration of DHM did not differ between commercial and non-profit milk banks. Carbohydrates, fat, calories, and cortisol were higher, and IgA was lower in DHM from a commercial milk bank. Lot-to-lot variability of all components, besides cortisol, was lower in commercial DHM.

Conclusion

Macronutrient composition and variability differ in DHM from commercial vs non-profit milk banks.