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Objective <p>Determine prenatal and neonatal factors that predict infantile outcomes in patients with congenital heart disease (CHD).</p> Study Design <p>Retrospective cohort of 415 neonates with CHD admitted to a neonatal intensive care unit (NICU). Statistical tests included Chi-square, Fisher’s Exact, Kruskal-Wallis, and multivariable logistic regression.</p> Results <p>Cardiac lesion type was associated with mortality, length of stay, and enteral feeding tube support at discharge (EFTD) (<i>p</i> ≤ 0.01). A genetic diagnosis and an extra-cardiac congenital anomaly were associated with higher odds of respiratory support needs at discharge (RSND) [OR 2.8 (95% CI: 1.2, 6.5); 4.8 (1.9, 11.8)] and EFTD [5.5 (2.9, 10.8); 3.4 (2.4–9.7)]. Lower birth weight was associated with higher odds of RSND [0.5 (0.38, 0.66)], and lower gestational age with higher odds of EFTD [0.84 (0.75, 0.95)].</p> Conclusion <p>Several factors predicted adverse outcomes in infants with CHD, helping to identify high-risk cases for targeted care and improved parental guidance.</p>

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Predicting the future for neonates with symptomatic congenital heart disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月13日

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  • Mahati Pidaparti,
  • Benjamin M. Helm,
  • Britney Reed,
  • Paulomi M. Chaudhry,
  • Gabrielle Geddes,
  • Melinda H. Markham,
  • Poonam M. Puranik,
  • Kristen R. Suhrie

摘要

Objective

Determine prenatal and neonatal factors that predict infantile outcomes in patients with congenital heart disease (CHD).

Study Design

Retrospective cohort of 415 neonates with CHD admitted to a neonatal intensive care unit (NICU). Statistical tests included Chi-square, Fisher’s Exact, Kruskal-Wallis, and multivariable logistic regression.

Results

Cardiac lesion type was associated with mortality, length of stay, and enteral feeding tube support at discharge (EFTD) (p ≤ 0.01). A genetic diagnosis and an extra-cardiac congenital anomaly were associated with higher odds of respiratory support needs at discharge (RSND) [OR 2.8 (95% CI: 1.2, 6.5); 4.8 (1.9, 11.8)] and EFTD [5.5 (2.9, 10.8); 3.4 (2.4–9.7)]. Lower birth weight was associated with higher odds of RSND [0.5 (0.38, 0.66)], and lower gestational age with higher odds of EFTD [0.84 (0.75, 0.95)].

Conclusion

Several factors predicted adverse outcomes in infants with CHD, helping to identify high-risk cases for targeted care and improved parental guidance.