Objective <p>To evaluate the influence of mode of delivery on repolarisation and QT interval in the neonatal electrocardiogram (ECG).</p> Study design <p>KUNO-Kids is a prospective, population-based birth cohort study. Neonates received an ECG within the first week of life; subgroups were divided according to mode of delivery. Effects on neonatal QT interval were tested by linear and logistic regression analyses, adjusting for age at ECG recording.</p> Results <p>In total, 712 neonates were included. The primary caesarean section group showed a significant higher mean QTc (regression coefficient 6.03, <i>p</i> = 0.033) and a significantly increased rate of prolonged QTc &gt;450 ms (odds ratio 2.4, <i>p</i> = 0.042), compared to the spontaneous delivery group.</p> Conclusion <p>The mode of delivery has a significant effect on neonatal QTc. Clinicians should consider this influence when deciding on postnatal and follow-up examinations, regarding additional risk factors for acquired long QT interval.</p>

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Influence of mode of delivery on neonatal QTc

  • Christina Eder,
  • Stephan Gerling,
  • Susanne Brandstetter,
  • Markus-Johann Dechant,
  • Angela Köninger,
  • Annegret Schnabel,
  • Christian Apfelbacher,
  • Sven Wellmann,
  • Michael Kabesch,
  • Andreas Ambrosch,
  • Petra A. Arndt,
  • Andrea Baessler,
  • Mark Berneburg,
  • Romuald Brunner,
  • Sara Fill Malfertheiner,
  • André Franke,
  • Robert Häsler,
  • Iris Heid,
  • Stefanie Heinze,
  • Wolfgang Högler,
  • Sebastian Kerzel,
  • Michael Koller,
  • Michael Leitzmann,
  • Áine Lennon,
  • David Rothfuß,
  • Martin Promm,
  • Bianca Schaub,
  • Stephan Weidinger,
  • Holger Michel

摘要

Objective

To evaluate the influence of mode of delivery on repolarisation and QT interval in the neonatal electrocardiogram (ECG).

Study design

KUNO-Kids is a prospective, population-based birth cohort study. Neonates received an ECG within the first week of life; subgroups were divided according to mode of delivery. Effects on neonatal QT interval were tested by linear and logistic regression analyses, adjusting for age at ECG recording.

Results

In total, 712 neonates were included. The primary caesarean section group showed a significant higher mean QTc (regression coefficient 6.03, p = 0.033) and a significantly increased rate of prolonged QTc >450 ms (odds ratio 2.4, p = 0.042), compared to the spontaneous delivery group.

Conclusion

The mode of delivery has a significant effect on neonatal QTc. Clinicians should consider this influence when deciding on postnatal and follow-up examinations, regarding additional risk factors for acquired long QT interval.