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Objectives <p>To explore the clinical and hemodynamic effects of sildenafil in extreme premature population with bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH).</p> Study design <p>Single-centre retrospective study on infants born &lt;28 weeks with BPD-PH on sildenafil. The respiratory severity score was assessed at four time points (72 h–4wks). Echocardiographic data were compared before and after sildenafil.</p> Results <p>Sixty-four infants were included. The mean gestational age was 26.1 ± 1.6 weeks. 30(47%) infants showed improvement in RSS, 17(26%) had no change and 17(26%) showed poor RSS. 15(88) in the poor RSS group had an early onset PH. The improved RSS group reduced tricuspid regurgitation (3.3 ± 0.6 to 2.7 ± 0.5 m/s, <i>p</i> = 0.007). The pulmonary acceleration time (PAAT), PAAT/RVET (right ventricular ejection time), and RV fractional area change showed improvement in all groups. The poor RSS group had high pretreatment systolic blood pressure (90.7 ± 8.8 vs 82.7 ± 4.4 mmHg, <i>p</i> = 0.04).</p> Conclusion <p>Variable clinical response to sildenafil warrants close monitoring of respiratory status.</p>

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Variable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension

  • 期刊论文

  • 发表日期：

    2026年2月5日

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  • Krishna Revanna Gopagondanahalli,
  • Jaime Maria Tan,
  • Joyce Khoo May Lyn,
  • Sreekanthan Sundararaghavan,
  • Arvind Sehgal,
  • Wei Di Ng,
  • Boon Siew Ooi,
  • Mei Chien Chua,
  • Yee Yin Tan,
  • Min Yu Tan,
  • Abdul Haium Abdul Alim,
  • Victor Samuel Rajadurai

摘要

Objectives

To explore the clinical and hemodynamic effects of sildenafil in extreme premature population with bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH).

Study design

Single-centre retrospective study on infants born <28 weeks with BPD-PH on sildenafil. The respiratory severity score was assessed at four time points (72 h–4wks). Echocardiographic data were compared before and after sildenafil.

Results

Sixty-four infants were included. The mean gestational age was 26.1 ± 1.6 weeks. 30(47%) infants showed improvement in RSS, 17(26%) had no change and 17(26%) showed poor RSS. 15(88) in the poor RSS group had an early onset PH. The improved RSS group reduced tricuspid regurgitation (3.3 ± 0.6 to 2.7 ± 0.5 m/s, p = 0.007). The pulmonary acceleration time (PAAT), PAAT/RVET (right ventricular ejection time), and RV fractional area change showed improvement in all groups. The poor RSS group had high pretreatment systolic blood pressure (90.7 ± 8.8 vs 82.7 ± 4.4 mmHg, p = 0.04).

Conclusion

Variable clinical response to sildenafil warrants close monitoring of respiratory status.