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Objective <p>Point-of-care (POC) testing offers expedited results with lower blood volume requirements than central laboratory (CL) tests, particularly for low-birth-weight infants.</p> Methods <p>A retrospective cohort included 118 patients with paired POC and CL tests within one hour in the first 14 postnatal days. Differences and agreement were assessed using linear mixed-effect models that account for within and between-subject variations.</p> Results <p>Compared to CL, POC testing underestimated sodium (6.0 mEq/L), potassium (0.1 mEq/L), chloride (5.1 mEq/L), and glucose (2.3 mg/dL), and overestimated hemoglobin (0.08 g/dL) and hematocrit (0.8%). Differences (CL- POC) varied by postnatal age and sample type, with larger differences for sodium and chloride that decreased with age and smaller differences in capillary and venous than arterial samples. Glucose and hemoglobin differences increased over time, while hematocrit remained stable.</p> Conclusions <p>POC results underestimated sodium, potassium, chloride, and glucose, and overestimated hemoglobin and hematocrit.</p>

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Evaluating the accuracy of point of care testing compared to standard laboratory testing among inborn infants in the neonatal intensive care unit

  • 期刊论文

  • 发表日期：

    2025年12月19日

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  • Isha Parikh,
  • Sepideh Saroukhani,
  • Matthew Rysavy,
  • Brian Chang,
  • Mar Romero-Lopez,
  • Lindsay F. Holzapfel

摘要

Objective

Point-of-care (POC) testing offers expedited results with lower blood volume requirements than central laboratory (CL) tests, particularly for low-birth-weight infants.

Methods

A retrospective cohort included 118 patients with paired POC and CL tests within one hour in the first 14 postnatal days. Differences and agreement were assessed using linear mixed-effect models that account for within and between-subject variations.

Results

Compared to CL, POC testing underestimated sodium (6.0 mEq/L), potassium (0.1 mEq/L), chloride (5.1 mEq/L), and glucose (2.3 mg/dL), and overestimated hemoglobin (0.08 g/dL) and hematocrit (0.8%). Differences (CL- POC) varied by postnatal age and sample type, with larger differences for sodium and chloride that decreased with age and smaller differences in capillary and venous than arterial samples. Glucose and hemoglobin differences increased over time, while hematocrit remained stable.

Conclusions

POC results underestimated sodium, potassium, chloride, and glucose, and overestimated hemoglobin and hematocrit.