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<p>Perinatal asphyxia is a critical event causing variable degrees of multiorgan dysfunction. Hypoxemic ischemic encephalopathy (HIE) features the brain exposure to asphyxia, and most of the underlying pathophysiology is a related to impaired blood flow and oxygen delivery to the brain. Cardiovascular compromise is common in this context and often necessitates initiation of inotropic support. In this article, we highlight the neonatal hemodynamics and its derangements, following asphyxia, and we highlight the pitfalls in the current hemodynamic approach.</p>

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Hemodynamics in infants with hypoxemic ischemic encephalopathy: pathophysiology and beyond

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Aimann Surak,
  • Georg M. Schmölzer,
  • Patrick J. McNamara,
  • Joseph Y. Ting,
  • Musab Alshareef,
  • Khorshid Mohammad

摘要

Perinatal asphyxia is a critical event causing variable degrees of multiorgan dysfunction. Hypoxemic ischemic encephalopathy (HIE) features the brain exposure to asphyxia, and most of the underlying pathophysiology is a related to impaired blood flow and oxygen delivery to the brain. Cardiovascular compromise is common in this context and often necessitates initiation of inotropic support. In this article, we highlight the neonatal hemodynamics and its derangements, following asphyxia, and we highlight the pitfalls in the current hemodynamic approach.