Scholarlink

Objective <p>To assess inter-specialty differences in the management of febrile neonates receiving prostaglandin E1 (PGE1) for duct-dependent congenital heart disease.</p> Study design <p>A cross-sectional, web-based survey was distributed to 800 neonatologists and pediatric cardiac intensivists in North America, Europe, and the Middle East. Respondents (<i>n</i> = 526) were queried regarding their management of a clinical vignette involving a febrile neonate on PGE1, including decisions about sepsis work-up, antibiotic administration, and lumbar puncture. Data were analyzed using chi-square tests and multivariate logistic regression.</p> Result <p>Pediatric cardiac intensivists were significantly more likely to initiate full sepsis work-up and antibiotic therapy (65.6% vs. 38.7%, <i>p</i> &lt; 0.001). Specialty was the only significant predictor of antibiotic administration (OR = 3.07, 95% CI: 1.76–4.40, <i>p</i> &lt; 0.001). No significant differences were found in lumbar puncture practices.</p> Conclusion <p>Significant inter-specialty variation exists in the management of febrile neonates on PGE1, highlighting the need for evidence-based guidelines to standardize care and optimize antimicrobial stewardship.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Inter-specialty differences in the management of febrile neonates on prostaglandin E1

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月24日

查看全文
  • Sharon Morag,
  • Alexander Lowenthal,
  • Hiba Abuelhija,
  • Uri Pollak

摘要

Objective

To assess inter-specialty differences in the management of febrile neonates receiving prostaglandin E1 (PGE1) for duct-dependent congenital heart disease.

Study design

A cross-sectional, web-based survey was distributed to 800 neonatologists and pediatric cardiac intensivists in North America, Europe, and the Middle East. Respondents (n = 526) were queried regarding their management of a clinical vignette involving a febrile neonate on PGE1, including decisions about sepsis work-up, antibiotic administration, and lumbar puncture. Data were analyzed using chi-square tests and multivariate logistic regression.

Result

Pediatric cardiac intensivists were significantly more likely to initiate full sepsis work-up and antibiotic therapy (65.6% vs. 38.7%, p < 0.001). Specialty was the only significant predictor of antibiotic administration (OR = 3.07, 95% CI: 1.76–4.40, p < 0.001). No significant differences were found in lumbar puncture practices.

Conclusion

Significant inter-specialty variation exists in the management of febrile neonates on PGE1, highlighting the need for evidence-based guidelines to standardize care and optimize antimicrobial stewardship.