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Objective <p>To investigate the phototherapy exposure in extremely preterm infants using different treatment protocols and devices.</p> Design <p>Cross-sectional observational study enrolling extremely preterm infants requiring light emitting diodes (LED) phototherapy during the first week of life. The duration of phototherapy applying various expert opinion-based treatment guidelines was calculated. Irradiance was measured, and spectral power was estimated.</p> Results <p>Forty-two preterm infants were studied. The phototherapy duration changed depending on the treatment protocol (overall <i>p</i> &lt; 0.001) and ranged from 0 to 72 h, with a median coefficient of variation of 66.6 [44–124]%. The spectral power was significantly different depending on the LED device (overall <i>p</i> &lt; 0.001) and ranged from 8.6 to 17.8 mW/nm, with a median coefficient of variation of 18.1 [18–18.3]%</p> Conclusions <p>The phototherapy exposure of preterm infants significantly varies both as cumulative duration of therapy and spectral power, due to different treatment protocols and devices.</p>

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Phototherapy exposure variability in extremely preterm neonates due to different treatment protocols and devices: cross-sectional study

  • 期刊论文

  • 发表日期：

    2025年11月5日

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  • Daniele De Luca,
  • Costanza Neri,
  • Vanessa Monin,
  • Vinod Bhutani

摘要

Objective

To investigate the phototherapy exposure in extremely preterm infants using different treatment protocols and devices.

Design

Cross-sectional observational study enrolling extremely preterm infants requiring light emitting diodes (LED) phototherapy during the first week of life. The duration of phototherapy applying various expert opinion-based treatment guidelines was calculated. Irradiance was measured, and spectral power was estimated.

Results

Forty-two preterm infants were studied. The phototherapy duration changed depending on the treatment protocol (overall p < 0.001) and ranged from 0 to 72 h, with a median coefficient of variation of 66.6 [44–124]%. The spectral power was significantly different depending on the LED device (overall p < 0.001) and ranged from 8.6 to 17.8 mW/nm, with a median coefficient of variation of 18.1 [18–18.3]%

Conclusions

The phototherapy exposure of preterm infants significantly varies both as cumulative duration of therapy and spectral power, due to different treatment protocols and devices.