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Objective <p>We describe a novel strategy of nasal intermittent positive pressure ventilation (NIPPV) to support patients with Grade 3 bronchopulmonary dysplasia (BPD).</p> Study design <p>This is a retrospective study of Grade 3 BPD patients treated with NIPPV and discharged from a single center from January 2020 to May 2024. Patients were grouped into discharged without tracheostomy vs with tracheostomy. Groups were assessed for clinical differences, and the NIPPV strategy is described.</p> Results <p>There were 28 non-tracheostomy and 17 tracheostomy patients. There were no differences in gestational age, birthweight, or respiratory severity score at key dates. Tracheostomy patients were more likely to have subglottic stenosis (53% vs 3.6%, <i>p</i> = 0.0001) and were older at discharge home [median 447 (411–479) vs 252 (184–309) days, <i>p</i> &lt; 0.0001].</p> Conclusion <p>A subset of Grade 3 BPD patients can be supported with NIPPV. The non-tracheostomy group had decreased length of stay compared to the tracheostomy group.</p>

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Nasal intermittent positive pressure ventilation in neonates with grade 3 bronchopulmonary dysplasia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月17日

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  • Mark F. Weems,
  • Vineet Lamba,
  • Sandeep Chilakala,
  • L. Brooke Murdock,
  • Divya Rana,
  • Rishika Sakaria,
  • Parul Zaveri,
  • Rangasamy Ramanathan,
  • Lindsay Burgess,
  • Kristen Dabov,
  • Mimi Harsono,
  • Patricia Hess,
  • Bhuvaneshwari Jagadesan,
  • Tiffany Jenkins,
  • Amanda Linz,
  • Ranjit Philip,
  • Emily Todd,
  • Kathryn Williams,
  • Nicole Yocum

摘要

Objective

We describe a novel strategy of nasal intermittent positive pressure ventilation (NIPPV) to support patients with Grade 3 bronchopulmonary dysplasia (BPD).

Study design

This is a retrospective study of Grade 3 BPD patients treated with NIPPV and discharged from a single center from January 2020 to May 2024. Patients were grouped into discharged without tracheostomy vs with tracheostomy. Groups were assessed for clinical differences, and the NIPPV strategy is described.

Results

There were 28 non-tracheostomy and 17 tracheostomy patients. There were no differences in gestational age, birthweight, or respiratory severity score at key dates. Tracheostomy patients were more likely to have subglottic stenosis (53% vs 3.6%, p = 0.0001) and were older at discharge home [median 447 (411–479) vs 252 (184–309) days, p < 0.0001].

Conclusion

A subset of Grade 3 BPD patients can be supported with NIPPV. The non-tracheostomy group had decreased length of stay compared to the tracheostomy group.